Daidzein‐Based Amphiphilic Small Molecular Antimicrobial Peptidomimetics as Novel Antimicrobial Agents with Anti‐Biofilm Activity

Z Hong, TT Yu, M Yasir, M Sara, DSC Black… - …, 2024 - Wiley Online Library
A new series of daidzein‐based short peptidomimetic compounds were developed. In this
study, we incorporated an alkyl chain with different chain lengths as hydrophobic groups …

[HTML][HTML] Polyphenylglyoxamide-based amphiphilic small molecular peptidomimetics as antibacterial agents with anti-biofilm activity

TT Yu, R Kuppusamy, M Yasir, MM Hassan… - International Journal of …, 2021 - mdpi.com
The rapid emergence of drug-resistant bacteria is a major global health concern.
Antimicrobial peptides (AMPs) and peptidomimetics have arisen as a new class of …

Smart Galactosidase‐Responsive Antimicrobial Dendron: Towards More Biocompatible Membrane‐Disruptive Agents

Z Shao, YD Xu, H Luo, K Hakobyan… - Macromolecular …, 2024 - Wiley Online Library
Antimicrobial resistance is a global healthcare challenge that urgently needs the
development of new therapeutic agents. Antimicrobial peptides and mimics thereof are …

Synthesis of short cationic antimicrobial peptidomimetics containing arginine analogues

L Baldassarre, F Pinnen, C Cornacchia… - Journal of Peptide …, 2012 - Wiley Online Library
Worldwide efforts are underway to develop new antimicrobial agents against bacterial
resistance. To identify new compounds with a good antimicrobial profile, we designed and …

Pyrazole derived ultra-short antimicrobial peptidomimetics with potent anti-biofilm activity

M Ahn, P Gunasekaran, G Rajasekaran, EY Kim… - European journal of …, 2017 - Elsevier
In this study, we report on the first chemical synthesis of ultra-short pyrazole-arginine based
antimicrobial peptidomimetics derived from the newly synthesized N-alkyl/aryl pyrazole …

An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro …

J Zhou, L Zhang, Y He, K Liu, F Zhang, H Zhang… - European Journal of …, 2021 - Elsevier
Due to the threat of escalating multi-drug resistant gram-negative bacteria to human health
and life, novel antimicrobial agents against gram-negative pathogens are urgently needed …

Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria

Y Chen, H Li, J Liu, R Zhong, H Li, S Fang, S Liu… - European Journal of …, 2021 - Elsevier
The emergence of bacterial multidrug resistance and the lack of new antimicrobial agents
urgently demand the discovery and development of novel antibacterials that avoid bacterial …

Antimicrobial activity of novel dendrimeric peptides obtained by phage display selection and rational modification

A Pini, A Giuliani, C Falciani, Y Runci… - Antimicrobial agents …, 2005 - Am Soc Microbiol
ABSTRACT A large 10-mer phage peptide library was panned against whole Escherichia
coli cells, and an antimicrobial peptide (QEKIRVRLSA) was selected. The peptide was …

Antibacterial Mechanism of a Novel Peptide Dendrocin‑ZM1 Against Staphylococcus aureus by Increasing Membrane Permeability

SS Seyedjavadi, M Razzaghi-Abyaneh… - International Journal of …, 2023 - Springer
Staphylococcus aureus is a prevalent pathogen responsible for healthcare and community-
acquired infections, which lead to elevated rates of fatality and morbidity. With the …

Rational design and synthesis of Oreoch-2 analogues as efficient broad-spectrum antimicrobial peptides

N Zhang, X Gu, D Song, P Zhang, N Zhang, W Chen… - Bioorganic …, 2022 - Elsevier
In recent years, bacterial resistance has risen sharply, which seriously endangers public
health due to the abuse of antibiotics and the lack of new antibiotics. Therefore, there is an …