Purpose A sensitive method was developed for the simultaneous determination of
midazolam and propofol in human plasma samples via modified quick, easy, cheap …

Midazolam is a benzodiazepine and is widely prescribed for preanesthesia or general
anesthesia. Overdose or intoxication cases of midazolam have been reported. In Japan …

Propofol is an important compound used for anaesthetic purposes in clinical practice.
Nevertheless, in the recent years, the use of propofol has also been reported for …

An analytical method which was used for the simultaneous detection and quantification of
propofol and its metabolites in human blood and urine by gas chromatography-tandem …

Propofol is a widely used intravenous anesthetic for sedation during the surgery and
worldwide propofol abuse has been frequently reported also. As an essential procedure for …

Propofol concentration in human plasma can be quantified by liquid chromatography
coupled mass spectrometry. Sample preparation usually requires solid phase extraction to …

Currently, pharmacokinetic–pharmacodynamic studies of sedatives and analgesics are
performed in neonates and children to find suitable dose regimens. As a result, sensitive …

A rapid, sensitive and selective liquid chromatography/electrospray mass spectrometry
(LC/ES‐MS) method was developed for the quantitative determination of the anaesthetic …

Propofol (PRO) is a hypnotic used to induce and maintain general anesthesia. A risk of drug–
drug interactions exists in cases of clinical co-administration of PRO and midazolam (MDZ) …

A gas chromatography-mass spectrometry (GC-MS) method for the determination of propofol
in human plasma has been developed and validated. Propofol was extracted from human …