Repurposing of chronically used drugs in cancer therapy: a chance to grasp

MA Hijazi, A Gessner, N El-Najjar - Cancers, 2023 - mdpi.com
Simple Summary Cancer mortalities are growing at an alarming pace around the globe, a
fact related to challenges, such as side effects, selectivity, and resistance, accompanied by …

Repurposing drugs targeting metabolic diseases for cancer therapeutics

J Pillai, A Ray, M Maan, M Dutta - Drug Discovery Today, 2023 - Elsevier
Highlights•Discovery of new drugs against cancer is of utmost importance.•Drug repurposing
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …

Unexploited antineoplastic effects of commercially available anti-diabetic drugs

P Papanagnou, T Stivarou, M Tsironi - Pharmaceuticals, 2016 - mdpi.com
The development of efficacious antitumor compounds with minimal toxicity is a hot research
topic. Numerous cancer cell targeted agents are evaluated daily in laboratories for their …

Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review

S Siddiqui, AJ Deshmukh, P Mudaliar… - Journal of the Egyptian …, 2022 - Springer
While majority of the current treatment approaches for cancer remain expensive and are
associated with several side effects, development of new treatment modalities takes a …

Repurposing old drugs in oncology: Opportunities with clinical and regulatory challenges ahead

RR Shah, PD Stonier - Journal of clinical pharmacy and …, 2019 - Wiley Online Library
What is known and objective In order to expedite the availability of drugs to treat cancers in a
cost‐effective manner, repurposing of old drugs for oncological indications is gathering …

Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics

A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs

A Olatunde, M Nigam, RK Singh, AS Panwar… - Cancer cell …, 2021 - Springer
Cancers are regarded as one of the main causes of death and result in high health burden
worldwide. The management of cancer include chemotherapy, surgery and radiotherapy …

Drug repurposing in oncology: a systematic review of randomized controlled clinical trials

I Ioakeim-Skoufa, N Tobajas-Ramos, E Menditto… - Cancers, 2023 - mdpi.com
Simple Summary Exploring the possibility of using well-known marketed drugs in new
therapeutic indications, commonly known as drug repurposing, offers certain advantages …

Repurposing non-cancer Drugs in Oncology–How many drugs are out there?

P Pantziarka, V Sukhatme, L Meheus, V Sukhatme… - bioRxiv, 2017 - biorxiv.org
Background Drug repurposing can speed up access to new therapeutic options for cancer
patients. With more than 2000 drugs approved worldwide and 6 relevant targets per drug on …

[HTML][HTML] Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions

L Fu, W Jin, J Zhang, L Zhu, J Lu, Y Zhen… - … Pharmaceutica Sinica B, 2022 - Elsevier
Drug repurposing or repositioning has been well-known to refer to the therapeutic
applications of a drug for another indication other than it was originally approved for …