Repurposing of chronically used drugs in cancer therapy: a chance to grasp
MA Hijazi, A Gessner, N El-Najjar - Cancers, 2023 - mdpi.com
Simple Summary Cancer mortalities are growing at an alarming pace around the globe, a
fact related to challenges, such as side effects, selectivity, and resistance, accompanied by …
fact related to challenges, such as side effects, selectivity, and resistance, accompanied by …
Repurposing drugs targeting metabolic diseases for cancer therapeutics
Highlights•Discovery of new drugs against cancer is of utmost importance.•Drug repurposing
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …
Unexploited antineoplastic effects of commercially available anti-diabetic drugs
P Papanagnou, T Stivarou, M Tsironi - Pharmaceuticals, 2016 - mdpi.com
The development of efficacious antitumor compounds with minimal toxicity is a hot research
topic. Numerous cancer cell targeted agents are evaluated daily in laboratories for their …
topic. Numerous cancer cell targeted agents are evaluated daily in laboratories for their …
Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review
S Siddiqui, AJ Deshmukh, P Mudaliar… - Journal of the Egyptian …, 2022 - Springer
While majority of the current treatment approaches for cancer remain expensive and are
associated with several side effects, development of new treatment modalities takes a …
associated with several side effects, development of new treatment modalities takes a …
Repurposing old drugs in oncology: Opportunities with clinical and regulatory challenges ahead
RR Shah, PD Stonier - Journal of clinical pharmacy and …, 2019 - Wiley Online Library
What is known and objective In order to expedite the availability of drugs to treat cancers in a
cost‐effective manner, repurposing of old drugs for oncological indications is gathering …
cost‐effective manner, repurposing of old drugs for oncological indications is gathering …
Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics
A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs
Cancers are regarded as one of the main causes of death and result in high health burden
worldwide. The management of cancer include chemotherapy, surgery and radiotherapy …
worldwide. The management of cancer include chemotherapy, surgery and radiotherapy …
Drug repurposing in oncology: a systematic review of randomized controlled clinical trials
I Ioakeim-Skoufa, N Tobajas-Ramos, E Menditto… - Cancers, 2023 - mdpi.com
Simple Summary Exploring the possibility of using well-known marketed drugs in new
therapeutic indications, commonly known as drug repurposing, offers certain advantages …
therapeutic indications, commonly known as drug repurposing, offers certain advantages …
Repurposing non-cancer Drugs in Oncology–How many drugs are out there?
P Pantziarka, V Sukhatme, L Meheus, V Sukhatme… - bioRxiv, 2017 - biorxiv.org
Background Drug repurposing can speed up access to new therapeutic options for cancer
patients. With more than 2000 drugs approved worldwide and 6 relevant targets per drug on …
patients. With more than 2000 drugs approved worldwide and 6 relevant targets per drug on …
[HTML][HTML] Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions
L Fu, W Jin, J Zhang, L Zhu, J Lu, Y Zhen… - … Pharmaceutica Sinica B, 2022 - Elsevier
Drug repurposing or repositioning has been well-known to refer to the therapeutic
applications of a drug for another indication other than it was originally approved for …
applications of a drug for another indication other than it was originally approved for …