Integration of multi-omics data from mouse diversity panel highlights mitochondrial dysfunction in non-alcoholic fatty liver disease
The etiology of non-alcoholic fatty liver disease (NAFLD), the most common form of chronic
liver disease, is poorly understood. To understand the causal mechanisms underlying …
liver disease, is poorly understood. To understand the causal mechanisms underlying …
Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a major risk factor leading to chronic liver
disease and type 2 diabetes. Here we chart liver metabolic activity and functionality in …
disease and type 2 diabetes. Here we chart liver metabolic activity and functionality in …
Utility of human relevant preclinical animal models in navigating NAFLD to MAFLD paradigm
Fatty liver disease is an emerging contributor to disease burden worldwide. The past
decades of work established the heterogeneous nature of non-alcoholic fatty liver disease …
decades of work established the heterogeneous nature of non-alcoholic fatty liver disease …
Changes in key mitochondrial lipids accompany mitochondrial dysfunction and oxidative stress in NAFLD
M Durand, M Coué, M Croyal, T Moyon… - Oxidative medicine …, 2021 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a dysmetabolic hepatic damage of increasing
severity: simple fat accumulation (steatosis), nonalcoholic steatohepatitis (NASH), and …
severity: simple fat accumulation (steatosis), nonalcoholic steatohepatitis (NASH), and …
Systems biology elucidates common pathogenic mechanisms between nonalcoholic and alcoholic-fatty liver disease
S Sookoian, CJ Pirola - PLoS One, 2013 - journals.plos.org
The abnormal accumulation of fat in the liver is often related either to metabolic risk factors
associated with metabolic syndrome in the absence of alcohol consumption (nonalcoholic …
associated with metabolic syndrome in the absence of alcohol consumption (nonalcoholic …
The transcriptomic signature of disease development and progression of nonalcoholic fatty liver disease
A longitudinal molecular model of the development and progression of nonalcoholic fatty
liver disease (NAFLD) over time is lacking. We have recently validated a high fat/sugar water …
liver disease (NAFLD) over time is lacking. We have recently validated a high fat/sugar water …
Transcriptional regulation in non-alcoholic fatty liver disease
S Steensels, J Qiao, BA Ersoy - Metabolites, 2020 - mdpi.com
Obesity is the primary risk factor for the pathogenesis of non-alcoholic fatty liver disease
(NAFLD), the worldwide prevalence of which continues to increase dramatically. The liver …
(NAFLD), the worldwide prevalence of which continues to increase dramatically. The liver …
Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease that is
associated with multiple metabolic disturbances, yet the metabolic pathways underlying its …
associated with multiple metabolic disturbances, yet the metabolic pathways underlying its …
Hepatic dysfunction caused by consumption of a high-fat diet
Obesity is a major human health crisis that promotes insulin resistance and, ultimately, type
2 diabetes. The molecular mechanisms that mediate this response occur across many highly …
2 diabetes. The molecular mechanisms that mediate this response occur across many highly …
Comparison of gene expression patterns between mouse models of nonalcoholic fatty liver disease and liver tissues from patients
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is the most common chronic
liver disorder in industrialized countries. Mouse models of NAFLD have been used in …
liver disorder in industrialized countries. Mouse models of NAFLD have been used in …