Apomorphine is obtained from morphine by cationic rearrangement of morphine and is used
in the diagnosis and treatment of Parkinson's disease and also in erectile dysfunction. A …

The halogenomorphides and halogendcodides are formed when the secondary alcoholic
hydroxyl groupof morphine or codeine is replaced by a halogen atom. Although …

Publisher Summary This chapter discusses the pharmacology and neurochemistry of
apomorphine. Apomorphine was first employed as a powerful emetic agent. Apomorphine …

IN recent years three broadly defined methods of approach to the chemistry of the morphine
alkaloids have been clearly discernible. The older fields, elucidation of structure of the …

Keyword (fr) SUBSTITUTION NUCLEOPHILE ISOMERISATION ALCALOIDE MECANISME
SN2 HETEROCYCLE OXYGENE AZOTE COMPOSE PENTACYCLIQUE PREPARATION …

The isomerization of morphine (I) to dihydromorphinone (II)(in acidic me-dium) in the
presence of noble metal catalysts is well known (1). We have observed that inthe course of …

Tritium-labeled apomorphine was synthesized from morphine and apomorphine with
specific activities of 3.62 X 103-1.88 X 106 dpm//ig with labeling occurring predominantly on …

The first known nuclear-alkylated morphine derivatives, methyldihydro-codeinone and
methyldihydromorphinone (Metopon) were prepared some 15 years ago (1) but in spite of …

Unfortunately, Pschorr was only able to obtain this last base in the form of a non-
crystallisable syrup, and to characterise and analyse it in combination with methyl iodide …

Pseudocodeine methyl ether can be hydro-genated to give, according to the conditions,
principally dihydropseudocodeine-A methyl ether or tetrahydropseudocodeine methyl ether …