Pro-spermatogonia (SG) serve as the gateway to spermatogenesis. Using single-cell RNA
sequencing (RNAseq), we studied the development of ProSG, their SG descendants and …

Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

Spermatogonial stem cells (SSCs) are essential for the generation of sperm and have
potential therapeutic value for treating male infertility, which afflicts> 100 million men world …

Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and are the
subject of considerable clinical interest, as 'SSC therapy'has the potential to cure some …

Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …

Precise separation of spermatogonial stem cells (SSCs) from progenitor spermatogonia that
lack stem cell activity and are committed to differentiation remains a challenge. To …

Spermatogonial stem cells (SSCs) are a subset of undifferentiated spermatogonia
responsible for ongoing spermatogenesis in mammalian testes. Spermatogonial stem cells …

Mammalian testis development is a complex and highly sophisticated process. To study the
dynamic change of normal testis development at the transcriptional level, we investigated …

Spermatogenesis is a dynamic developmental process that includes stem cell proliferation
and differentiation, meiotic cell divisions and extreme chromatin condensation. Although …