Single-cell RNAseq analysis of testicular germ and somatic cell development during the perinatal period
Pro-spermatogonia (SG) serve as the gateway to spermatogenesis. Using single-cell RNA
sequencing (RNAseq), we studied the development of ProSG, their SG descendants and …
sequencing (RNAseq), we studied the development of ProSG, their SG descendants and …
The neonatal and adult human testis defined at the single-cell level
Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
A comprehensive roadmap of murine spermatogenesis defined by single-cell RNA-seq
Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
Transcriptome profiling reveals signaling conditions dictating human spermatogonia fate in vitro
Spermatogonial stem cells (SSCs) are essential for the generation of sperm and have
potential therapeutic value for treating male infertility, which afflicts> 100 million men world …
potential therapeutic value for treating male infertility, which afflicts> 100 million men world …
A single-cell view of spermatogonial stem cells
K Tan, MF Wilkinson - Current opinion in cell biology, 2020 - Elsevier
Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and are the
subject of considerable clinical interest, as 'SSC therapy'has the potential to cure some …
subject of considerable clinical interest, as 'SSC therapy'has the potential to cure some …
[HTML][HTML] The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids
Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
TSPAN8 expression distinguishes spermatogonial stem cells in the prepubertal mouse testis
K Mutoji, A Singh, T Nguyen… - Biology of …, 2016 - academic.oup.com
Precise separation of spermatogonial stem cells (SSCs) from progenitor spermatogonia that
lack stem cell activity and are committed to differentiation remains a challenge. To …
lack stem cell activity and are committed to differentiation remains a challenge. To …
Transcriptional and translational heterogeneity among neonatal mouse spermatogonia
BP Hermann, KN Mutoji, EK Velte, D Ko… - Biology of …, 2015 - academic.oup.com
Spermatogonial stem cells (SSCs) are a subset of undifferentiated spermatogonia
responsible for ongoing spermatogenesis in mammalian testes. Spermatogonial stem cells …
responsible for ongoing spermatogenesis in mammalian testes. Spermatogonial stem cells …
Transcriptome profiling of the developing postnatal mouse testis using next-generation sequencing
W Gong, LL Pan, Q Lin, YY Zhou, CQ Xin… - Science China Life …, 2013 - Springer
Mammalian testis development is a complex and highly sophisticated process. To study the
dynamic change of normal testis development at the transcriptional level, we investigated …
dynamic change of normal testis development at the transcriptional level, we investigated …
Unraveling transcriptome dynamics in human spermatogenesis
SZ Jan, TL Vormer, A Jongejan, MD Röling… - …, 2017 - journals.biologists.com
Spermatogenesis is a dynamic developmental process that includes stem cell proliferation
and differentiation, meiotic cell divisions and extreme chromatin condensation. Although …
and differentiation, meiotic cell divisions and extreme chromatin condensation. Although …