Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective
treatment for selected patients with acute myeloid leukemia (AML) and relies on a “graft …

Allogeneic stem cell transplantation (allo-SCT) can be a curative treatment for patients with a
hematologic malignancy due to alloreactive T cell responses recognizing minor …

After allogeneic stem cell transplantation (alloSCT), several immune checkpoints play an
important role in the antileukemic immune response in the bone marrow (BM) …

Adoptive natural regulatory T cell (nTreg) therapy has improved the outcome for patients
suffering from graft-versus-host disease (GVHD) following allogeneic hematopoietic cell …

The microenviroment of acute myelogenous leukemia (AML) is suppressive for immune
effector cells. Regulatory T cells (Tregs) have been recognized as a contributor factor and …

Donor lymphocyte infusion (DLI) is an effective approach to treat acute myelogenous
leukemia (AML) relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) …

Donor T cells play a pivotal role in the graft-versus-tumor effect after allogeneic
hematopoietic stem cell transplantation. Regulatory T cells (Tregs) may reduce alloreactivity …

While research on T cell exhaustion in context of cancer particularly focuses on CD8+
cytotoxic T cells, the role of inhibitory receptors on CD4+ T-helper cells have remained …

The success of allogeneic hematopoietic stem cell transplantation (HSCT) depends on the
infusion of benign stem cells as well as lymphocytes capable of participating in a graft …

Allogeneic hematopoietic stem cell transplantation is a potentially curative procedure for
many malignant diseases. Donor T cells prevent disease recurrence via graft-versus …