Collective gradient sensing and chemotaxis: modeling and recent developments
BA Camley - Journal of Physics: Condensed Matter, 2018 - iopscience.iop.org
Cells measure a vast variety of signals, from their environment's stiffness to chemical
concentrations and gradients; physical principles strongly limit how accurately they can do …
concentrations and gradients; physical principles strongly limit how accurately they can do …
[HTML][HTML] Collective chemotaxis through noisy multicellular gradient sensing
Collective cell migration in response to a chemical cue occurs in many biological processes
such as morphogenesis and cancer metastasis. Clusters of migratory cells in these systems …
such as morphogenesis and cancer metastasis. Clusters of migratory cells in these systems …
Emergent collective chemotaxis without single-cell gradient sensing
Many eukaryotic cells chemotax, sensing and following chemical gradients. However,
experiments have shown that even under conditions when single cells do not chemotax …
experiments have shown that even under conditions when single cells do not chemotax …
Cell-to-cell variation sets a tissue-rheology–dependent bound on collective gradient sensing
When a single cell senses a chemical gradient and chemotaxes, stochastic receptor–ligand
binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to …
binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to …
[HTML][HTML] Accuracy of direct gradient sensing by cell-surface receptors
RG Endres, NS Wingreen - Progress in biophysics and molecular biology, 2009 - Elsevier
Chemotactic cells of eukaryotic organisms are able to accurately sense shallow chemical
concentration gradients using cell-surface receptors. This sensing ability is remarkable as …
concentration gradients using cell-surface receptors. This sensing ability is remarkable as …
Emergent versus individual-based multicellular chemotaxis
Multicellular chemotaxis can occur via individually chemotaxing cells that are mechanically
coupled. Alternatively, it can emerge collectively, from cells chemotaxing differently in a …
coupled. Alternatively, it can emerge collectively, from cells chemotaxing differently in a …
Accuracy of direct gradient sensing by single cells
RG Endres, NS Wingreen - Proceedings of the National …, 2008 - National Acad Sciences
Many types of cells are able to accurately sense shallow gradients of chemicals across their
diameters, allowing the cells to move toward or away from chemical sources. This …
diameters, allowing the cells to move toward or away from chemical sources. This …
Physical limits on cellular sensing of spatial gradients
Many eukaryotic cells are able to detect chemical gradients by directly measuring spatial
concentration differences. The precision of such gradient sensing is limited by fluctuations in …
concentration differences. The precision of such gradient sensing is limited by fluctuations in …
Receptor noise and directional sensing in eukaryotic chemotaxis
Chemotacting eukaryotic cells are able to detect very small chemical gradients (<?
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format?>∼<? format?> 1%) for a large range of background concentrations. For these …
Receptor noise limitations on chemotactic sensing
Chemotactic eukaryotic cells are able to detect chemoattractant gradients that are both
shallow and have a low background concentration. Under these conditions, the noise in the …
shallow and have a low background concentration. Under these conditions, the noise in the …