Mammalian spermatogenesis is a progressive process comprising spermatogonial
proliferation, spermatocytic meiosis, and later spermiogenesis, which is considered to be …

The anticancer agent, 5-aza-2′-deoxycytidine (5-azaCdR, decitabine), causes DNA
hypomethylation and a robust, dose-dependent disruption of spermatogenesis. Previously …

Genomic methylation patterns originate during gametogenesis and are postulated to be
involved in important developmental events, including gene regulation, embryogenesis, and …

Because of the ability of cytidine analogues, such as 5‐aza‐2′‐deoxycytidine, to
incorporate into DNA and lead to decreases in DNA methylation, there has recently been …

To investigate the changes in the levels of DNA methylation in the testis during development
after neonatal transient exposure to DNA methyltransferase (DNMT) inhibitors, we orally …

Aza-2′-deoxycitidine (5-Aza), an anticancer agent, results in substantial toxicity to male
reproduction, causing a decline in sperm quality associated with reduced testosterone …

The objective was to evaluate the effects of 5-AZA-2′-deoxycytidine (5-AZA-CdR) on
postnatal development and reproductive capacity. Pregnant mice were administered 1 mg …

Methylation of cytosine residues in mammalian DNA is established during gametogenesis
and embryogenesis; it plays an important role in gene regulation and normal embryonic …

Epigenetic processes such as DNA methylation are essential for processes of gene
expression in normal mammalian development. DNA methyltransferases (DNMT) are …

Testicular toxicity is a frequent adverse effect of cancer chemotherapy that has no effective
clinical biomarker. To find new biomarkers, we focused on epigenetic mechanisms in the …