Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …

With a widespread opioid epidemic and profound biopsychosocial implications, chronic pain
is a multifaceted public health issue requiring urgent attention. The treatment of chronic pain …

Microglia are the resident macrophages in the central nervous system (CNS). Any insult to
the CNS homeostasis will induce a rapid change in microglia morphology, gene expression …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Evidence indicates that central glial activation depends on nerve inputs from the site of injury
and release of chemical mediators. Hematogenous immune cells may migrate to/infiltrate …

Pain is a defense system that responds rapidly to harmful internal and external stimuli
through the somatosensory neuronal pathway. However, damage to the nervous system …

Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve
injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma …

Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

Management of chronic pain, such as nerve-injury-induced neuropathic pain associated
with diabetic neuropathy, viral infection, and cancer, is a real clinical challenge. Major …