Findings of epidemiologic studies focusing on the association between one-carbon
metabolism-related micronutrients and breast cancer risk, along with the involvement of …

Background: Some micronutrients like folate, vitamin B12, B6, and B2 are the source of
coenzymes, which participate in one-carbon metabolism. Any disruption in this metabolism …

One-carbon metabolism facilitates the crosstalk between genetic and epigenetic processes
and plays critical roles in both DNA methylation and DNA synthesis, making it a good …

Folate, vitamin B6, vitamin B12, methionine, choline, and betaine are nutrients involved in
one-carbon metabolism and have been hypothesized to reduce the risk of breast cancer …

(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and
methionine, may influence breast cancer (BC) risk through their role in one-carbon …

Abnormal methylation in gene promoters is a hallmark of the cancer genome; however,
factors that may influence promoter methylation have not been well elucidated. As the one …

This study aimed to examine the joint effects of folate intake, polymorphisms of 5, 10-
methylenetetrahydrofolate reductase (MTHFR), methionine synthesis reductase (MTRR) and …

The epidemiological literature reports inconsistent associations between consumption or
circulating concentrations of micronutrients and breast cancer risk. We investigated …

Folate is involved in DNA synthesis, repair, and methylation. It has been hypothesized that
high intake of folate may reduce the risk of human cancers, including cancer of the breast …

Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens
(CEs), using S-adenosylmethionine (SAM) as a methyl donor. Several studies have …