Blood− brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

R Prakash, ST Carmichael - Current opinion in neurology, 2015 - journals.lww.com
Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a
long way; however, we lack a clear understanding of the course of BBB disruption and BBB …

Blood-brain barrier dysfunction and recovery after ischemic stroke

X Jiang, AV Andjelkovic, L Zhu, T Yang… - Progress in …, 2018 - Elsevier
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

Blood–brain barrier pathophysiology in traumatic brain injury

A Chodobski, BJ Zink… - Translational stroke …, 2011 - Springer
The blood–brain barrier (BBB) is formed by tightly connected cerebrovascular endothelial
cells, but its normal function also depends on paracrine interactions between the brain …

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

D Shlosberg, M Benifla, D Kaufer… - Nature Reviews …, 2010 - nature.com
Traumatic brain injury (TBI) is the leading cause of death in young adults and children. The
treatment of TBI in the acute phase has improved substantially; however, the prevention and …

Blood–brain barrier breakdown in acute and chronic cerebrovascular disease

Y Yang, GA Rosenberg - Stroke, 2011 - Am Heart Assoc
Disruptions of the blood–brain barrier (BBB) and edema formation both play key roles in the
development of neurological dysfunction in acute and chronic cerebral ischemia. Animal …

Pathophysiology of blood–brain barrier permeability throughout the different stages of ischemic stroke and its implication on hemorrhagic transformation and recovery

S Bernardo-Castro, JA Sousa, A Brás, C Cecília… - Frontiers in …, 2020 - frontiersin.org
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …

Blood—brain barrier breakdown involves four distinct stages of vascular damage in various models of experimental focal cerebral ischemia

M Krueger, I Bechmann, K Immig… - Journal of Cerebral …, 2015 - journals.sagepub.com
Ischemic stroke not only impairs neuronal function but also affects the cerebral vasculature
as indicated by loss of blood—brain barrier (BBB) integrity. Therefore, therapeutical …

Response of the cerebral vasculature following traumatic brain injury

A Salehi, JH Zhang, A Obenaus - Journal of Cerebral Blood …, 2017 - journals.sagepub.com
The critical role of the vasculature and its repair in neurological disease states is beginning
to emerge particularly for stroke, dementia, epilepsy, Parkinson's disease, tumors and …

Blood-brain barrier protection as a therapeutic strategy for acute ischemic stroke

AE Sifat, B Vaidya, TJ Abbruscato - The AAPS Journal, 2017 - Springer
The blood-brain barrier (BBB) is a vital component of the neurovascular unit (NVU)
containing tight junctional (TJ) proteins and different ion and nutrient transporters which …

[HTML][HTML] Role of microvascular disruption in brain damage from traumatic brain injury

AF Logsdon, BP Lucke-Wold, RC Turner… - Comprehensive …, 2015 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is acquired from an external force, which can inflict devastating
effects to the brain vasculature and neighboring neuronal cells. Disruption of vasculature is …