CKD-induced wingless/Integration1 inhibitors and phosphorus cause the CKD–mineral and bone disorder

Y Fang, C Ginsberg, M Seifert, O Agapova… - Journal of the …, 2014 - journals.lww.com
In chronic kidney disease, vascular calcification, renal osteodystrophy, and phosphate
contribute substantially to cardiovascular risk and are components of CKD–mineral and …

The chronic kidney disease—Mineral bone disorder (CKD-MBD): Advances in pathophysiology

KA Hruska, T Sugatani, O Agapova, Y Fang - Bone, 2017 - Elsevier
The causes of excess cardiovascular mortality associated with chronic kidney disease
(CKD) have been attributed in part to the CKD-mineral bone disorder syndrome (CKD-MBD) …

Repression of osteocyte Wnt/β‐catenin signaling is an early event in the progression of renal osteodystrophy

Y Sabbagh, FG Graciolli, S O'Brien… - Journal of Bone and …, 2012 - academic.oup.com
Chronic kidney disease–mineral bone disorder (CKD‐MBD) is defined by abnormalities in
mineral and hormone metabolism, bone histomorphometric changes, and/or the presence of …

[HTML][HTML] Early chronic kidney disease–mineral bone disorder stimulates vascular calcification

Y Fang, C Ginsberg, T Sugatani, MC Monier-Faugere… - Kidney international, 2014 - Elsevier
The chronic kidney disease–mineral and bone disorder (CKD–MBD) syndrome is an
extremely important complication of kidney diseases. Here we tested whether CKD–MBD …

The connections between vascular calcification and bone health

JB Cannata-Andia, P Roman-Garcia… - Nephrology Dialysis …, 2011 - academic.oup.com
Vascular calcification, bone loss and increased fracture risk are age-associated disorders.
Several epidemiological studies have suggested a relationship between vascular …

Pathophysiology of Chronic Kidney Disease Mineral Bone Disorder (CKD‐MBD)

KA Hruska, M Seifert - Primer on the Metabolic Bone Diseases …, 2013 - Wiley Online Library
This chapter talks about pathophysiology of chronic kidney disease mineral bone disorder
(CKD‐MBD). It discusses the pathogenetic factors such as fibroblast growth factor 23 …

[HTML][HTML] Circulating levels of sclerostin but not DKK1 associate with laboratory parameters of CKD-MBD

GJ Behets, L Viaene, B Meijers, F Blocki… - PLoS …, 2017 - journals.plos.org
Introduction Mounting evidence indicates that a disturbed Wnt–β-catenin signaling may be
involved in the pathogenesis of chronic kidney disease-mineral and bone and mineral …

[HTML][HTML] SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling

J Voelkl, TTD Luong, R Tuffaha… - The Journal of …, 2018 - Am Soc Clin Investig
Medial vascular calcification, associated with enhanced mortality in chronic kidney disease
(CKD), is fostered by osteo-/chondrogenic transdifferentiation of vascular smooth muscle …

Chronic hyperphosphatemia and vascular calcification are reduced by stable delivery of soluble klotho

JM Hum, LM O'Bryan, AK Tatiparthi… - Journal of the …, 2017 - journals.lww.com
Abstract αKlotho (αKL) regulates mineral metabolism, and diseases associated with αKL
deficiency are characterized by hyperphosphatemia and vascular calcification (VC). αKL is …

[HTML][HTML] Sclerostin and DKK1: new players in renal bone and vascular disease

P Evenepoel, P D'haese, V Brandenburg - Kidney international, 2015 - Elsevier
For more than a decade, the Wnt–β-catenin pathway has been the focus of intense basic
and clinical research in the bone field because of its importance in skeletal development …