Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection

M Lyu, CL Yan, HX Liu, TY Wang, XH Shi, JP Liu… - Scientific Reports, 2017 - nature.com
Although Danhong injection (DHI) is the most widely prescribed Chinese medicine for both
stroke and coronary artery disease (CAD), its underlying common molecular mechanisms …

Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation

TF Cheng, J Zhao, QL Wu, HW Zeng, YT Sun… - Phytomedicine, 2020 - Elsevier
Abstract Background Compound Dan Zhi tablet (DZT) is a commonly used traditional
Chinese medicine formula. It has been used for the treatment of ischemic stroke for many …

Danhong injection in cardiovascular and cerebrovascular diseases: pharmacological actions, molecular mechanisms, and therapeutic potential

X Feng, Y Li, Y Wang, L Li, PJ Little, S Xu… - Pharmacological Research, 2019 - Elsevier
Cardiovascular and cerebrovascular diseases are the main cause of mortality worldwide,
currently with less than optimum therapeutic options. Danhong injection (DHI) is a medicinal …

Bioactivity-integrated UPLC/Q-TOF–MS of Danhong injection to identify NF-κB inhibitors and anti-inflammatory targets based on endothelial cell culture and network …

X Jiang, B Lv, P Li, X Ma, T Wang, Q Zhou… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance Danhong injection (DHI) is a traditional Chinese medicine
injection that has been widely used in therapy for cardiovascular diseases. However, neither …

Systems Pharmacology‐Based Approach to Comparatively Study the Independent and Synergistic Mechanisms of Danhong Injection and Naoxintong Capsule in …

J Zhu, X Yi, Y Zhang, Z Pan, L Zhong… - Evidence‐Based …, 2019 - Wiley Online Library
To provide evidence for the better clinical use of traditional Chinese medicine preparations
(TCMPs), comparison of the pharmacological mechanisms between TCMPs with similar …

Mechanism of Sanhua decoction in the treatment of ischemic stroke based on network pharmacology methods and experimental verification

YingHuang, S Gao, Z Gong, W Li… - BioMed research …, 2022 - Wiley Online Library
Objective. The mechanism of action of Sanhua Decoction (SHD) in the treatment of ischemic
stroke (IS) was analyzed based on the network pharmacology technology, and the …

[HTML][HTML] Mechanism of action of Daqinjiao decoction in treating cerebral small vessel disease explored using network pharmacology and molecular docking …

Z Wang, M Li, W Li, J Ouyang, X Gou, Y Huang - Phytomedicine, 2023 - Elsevier
Background and purpose Cerebral small vessel disease (CSVD) is a clinically commonly-
seen slow-progressing cerebral vascular disease. As a classic Chinese formula for the …

Integrating network pharmacology and experimental validation to decipher the mechanism of action of Huanglian Jiedu decoction in treating atherosclerosis

J Liang, Y Huang, Z Mai, Q Zhan, H Lin… - Drug Design …, 2021 - Taylor & Francis
Background This study used network pharmacology, molecular docking and experimental
validation to assess the effects of Huanglian Jiedu Decoction (HLJDD) on atherosclerosis …

Amelioration of Danhong injection on the lipopolysaccharide-stimulated systemic acute inflammatory reaction via multi-target strategy

LN Gao, YL Cui, QS Wang, SX Wang - Journal of ethnopharmacology, 2013 - Elsevier
Ethnopharmacological relevance Systemic inflammatory response syndrome (SIRS),
leading to dire consequences, is a serious and fatal disease in clinic. Danhong injection …

Network pharmacology and experimental validation-based approach to understand the effect and mechanism of Taohong Siwu Decoction against ischemic stroke

L Pan, C Peng, L Wang, L Li, S Huang, C Fei… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Taohong Siwu Decoction (THSWD) is a classic
prescription of traditional Chinese medicine that is mainly used for promoting blood …