Hospitalized preterm infants receive frequent and often prolonged exposures to antibiotics
because they are vulnerable to infection. It is not known whether the short-term effects of …

Abstract Development of the preterm infant gut microbiota is emerging as a critical research
priority 1. Since preterm infants almost universally receive early and often extended …

Intestinal host-microbiota interactions during the first year of life are critical for infant
development. Early-life antibiotic exposures disrupt stereotypical gut microbiota maturation …

Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have
pronounced effects on gut microbiome development and selection of antimicrobial …

Background Antibiotic-resistant (AR) bacteria are a global threat. AR bacteria can be
acquired in early life and have long-term sequelae. Limiting the spread of antibiotic …

Highlights•Neonatal and pediatric populations routinely receive antibiotic
treatment.•Disrupting the developing infant gut microbiota may have long-term metabolic …

Background Probiotic use in preterm infants can mitigate the impact of antibiotic exposure
and reduce rates of certain illnesses; however, the benefit on the gut resistome, the …

The gut microbiota plays important roles in nutrient absorption, immune system
development, and pathogen colonization resistance. Perturbations early in life may be …

Antibiotic resistance in pathogens is extensively studied, and yet little is known about how
antibiotic resistance genes of typical gut bacteria influence microbiome dynamics. Here, we …

Background The human gut microbiome harbors a collection of bacterial antimicrobial
resistance genes (ARGs) known as the resistome. The factors associated with establishment …