[HTML][HTML] Multi-sensory gamma stimulation ameliorates Alzheimer's-associated pathology and improves cognition

AJ Martorell, AL Paulson, HJ Suk, F Abdurrob… - Cell, 2019 - cell.com
We previously reported that inducing gamma oscillations with a non-invasive light flicker
(gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual …

Gamma entrainment binds higher-order brain regions and offers neuroprotection

C Adaikkan, SJ Middleton, A Marco, PC Pao, H Mathys… - Neuron, 2019 - cell.com
Neuronal and synaptic loss is characteristic in many neurodegenerative diseases, such as
frontotemporal dementia and Alzheimer's disease. Recently, we showed that inducing …

A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer's disease

Q He, KM Colon‐Motas, AF Pybus… - … Research & Clinical …, 2021 - Wiley Online Library
Introduction We and collaborators discovered that flickering lights and sound at gamma
frequency (40 Hz) reduce Alzheimer's disease (AD) pathology and alter immune cells and …

[HTML][HTML] Gamma oscillations in Alzheimer's disease and their potential therapeutic role

A Traikapi, N Konstantinou - Frontiers in systems neuroscience, 2021 - frontiersin.org
Despite decades of research, Alzheimer's Disease (AD) remains a lethal neurodegenerative
disorder for which there are no effective treatments. This review examines the latest …

Optogenetic gamma stimulation rescues memory impairments in an Alzheimer's disease mouse model

G Etter, S van der Veldt, F Manseau… - Nature …, 2019 - nature.com
Abstract Slow gamma oscillations (30–60 Hz) correlate with retrieval of spatial memory.
Altered slow gamma oscillations have been observed in Alzheimer's disease. Here, we use …

Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer's disease model mice

M Soula, A Martín-Ávila, Y Zhang, A Dhingra… - Nature …, 2023 - nature.com
There is a demand for noninvasive methods to ameliorate disease. We investigated whether
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …

Gamma frequency entrainment attenuates amyloid load and modifies microglia

HF Iaccarino, AC Singer, AJ Martorell, A Rudenko… - Nature, 2016 - nature.com
Abstract Changes in gamma oscillations (20–50 Hz) have been observed in several
neurological disorders. However, the relationship between gamma oscillations and cellular …

[HTML][HTML] An update on the use of gamma (multi) sensory stimulation for Alzheimer's disease treatment

V Manippa, A Palmisano, M Filardi, D Vilella… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is characterized by reduced fast brain oscillations in the gamma
band (γ,> 30 Hz). Several animal studies show that inducing gamma oscillations through …

Optimal flickering light stimulation for entraining gamma waves in the human brain

K Lee, Y Park, SW Suh, SS Kim, DW Kim, J Lee… - Scientific reports, 2021 - nature.com
Although light flickering at 40 Hz reduced Alzheimer's disease (AD) pathologies in mice by
entraining gamma waves, it failed to reduce cerebral amyloid burden in a study on six …

Gamma entrainment: impact on neurocircuits, glia, and therapeutic opportunities

C Adaikkan, LH Tsai - Trends in Neurosciences, 2020 - cell.com
Studies have shown that gamma oscillations (30–100 Hz) are relevant for neurocircuit
function, behavior, and memory. To examine a possible causal contribution of gamma …