In pursuit of potential agents to treat Chagas disease and leishmaniasis, we report the
design, synthesis, and identification novel naphthoquinone hydrazide-based molecular …

In this article, a series of 29 new pyrimidine N‐acylhydrazone hybrids were synthesized and
evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi protozoa that …

Bioprospecting and synthesis of strategically designed molecules have been used in the
search for drugs that can be in leishmaniasis. Hydrazones (HDZ) are promising compounds …

Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1, 4-
naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their …

Chagas disease affects around 8 million people worldwide and its treatment depends on
only two nitroheterocyclic drugs, benznidazole (BZD) and nifurtimox (NFX). Both drugs have …

Background: Chagas disease is a public health problem caused by Trypanosoma cruzi.
Cruzain is a pharmacological target for designing a new drug against this parasite …

A series of twenty phthalazinyl-hydrazones were synthesized and tested as potential anti-
Trypanosoma cruzi agents. The phthalazines containing 5-nitroheteroaryl moiety 3l and 3m …

Nitric oxide (NO) represents a valuable target to design antitrypanosomal agents by its high
toxicity against trypanosomatids and minimal side effects on host macrophages. The …

A new series of pyrazolo [3, 4-d] pyridazin-7-one derivatives were synthesised and
evaluated for their in vitro antileishmanial activity against Leishmania amazonensis …

In this paper, we report the structural design, synthesis, trypanocidal activity and docking
studies of novel quinoxaline-N-acylhydrazone (NAH) derivatives, planned as cruzain …