Objective Short-course aminoglycosides as adjunctive empirical therapy to β-lactams in
patients with a clinical suspicion of sepsis are used to broaden antibiotic susceptibility …

Background. Metaanalyses failed to demonstrate clinical benefits of beta lactam plus
aminoglycoside combination therapy compared to beta lactam monotherapy in patients with …

Objective. The objective of the proposed trial is to investigate whether transitioning to early
oral therapy is as safe and effective as remaining on IV therapy for the duration of treatment …

Importance Management of gram-negative bloodstream infections (GN-BSIs) with oral
antibiotics is highly variable. Objective To examine the transition from intravenous (IV) to oral …

To test the hypothesis that the addition of an aminoglycoside to a β-lactam antibiotic could
provide better outcomes than β-lactam monotherapy for the initial empirical treatment of …

Purpose Optimal antimicrobial treatment duration for Gram-negative bloodstream infection
(BSI) remains unclear. This retrospective cohort study examined effectiveness of short (7–10 …

There are important gaps in the literature regarding the role and timing of oral therapy for
Gram-negative bloodstream infections (GN-BSIs). To better understand contemporary …

Background Trials supporting shorter durations of antibiotic therapy for Gram-negative
bloodstream infections (GN-BSI) have recently been published. However, adoption of these …

Background Combination therapy in the treatment of sepsis, especially the value of
combining a β-Lactam antibiotic with an aminoglycoside, has been discussed. This …

Objectives Aminoglycosides and β-lactams have been recommended for treatment of
sepsis/septic shock despite a lack of mortality benefit. Previous studies have examined …