Abstract EF-hand Ca 2+-binding proteins (CBPs), such as S100 proteins (S100s) and
calmodulin (CaM), are signaling proteins that undergo conformational changes upon …

The EF hand, a helix− loop− helix structure, is one of the most common motifs found in
animal genomes, and EF-hand Ca2+-binding proteins (EFCaBPs) are widely distributed …

EF-hand calcium binding proteins have remarkable sequence homology and structural
similarity, yet their response to binding of calcium is diverse and they function in a wide …

Small-angle X-ray and neutron scattering have proven extremely useful for studying the
evolutionarily related dumbbell-shaped Ca {sup 2+}-binding proteins calmodulin and …

Abstract Calcium (Ca 2+) sensor proteins are critical and ubiquitous mediators of Ca 2+
messages in eukaryotic cells. These proteins “sense” local changes in intracellular Ca 2+ …

The S100A1 protein mediates a wide variety of physiological processes through its binding
of calcium (Ca 2+) and endogenous target proteins. S100A1 presents two Ca 2+-binding …

Calcium signaling pathways control a variety of cellular events such as gene transcription,
protein phosphorylation, nucleotide metabolism, and ion transport. These pathways often …

The S100 proteins comprise 25 calcium-signalling members of the EF-hand protein family.
Unlike typical EF-hand signalling proteins such as calmodulin and troponin-C, the S100 …

Ca2+, as a messenger of signal transduction, regulates numerous target molecules via
Ca2+‐induced conformational changes. Investigation into the determinants for Ca2+ …

EF-hand calcium binding proteins (CaBPs) share strong sequence homology, but exhibit
great diversity in structure and function. Thus although calmodulin (CaM) and calcineurin B …