The induction of epigenetic regulation of PROS1 gene in lung fibroblasts by gold nanoparticles and implications for potential lung injury

CT Ng, ST Dheen, WCG Yip, CN Ong, BH Bay… - Biomaterials, 2011 - Elsevier
Advances in nanotechnology have given rise to the rapid development of novel applications
in biomedicine. However, our understanding in the risks and health safety of nanomaterials …

Genomic instability of gold nanoparticle treated human lung fibroblast cells

JJ Li, SL Lo, CT Ng, RL Gurung, D Hartono, MP Hande… - Biomaterials, 2011 - Elsevier
Gold nanoparticles (AuNPs) are one of the most versatile and widely researched materials
for novel biomedical applications. However, the current knowledge in their toxicological …

Altered protein expression profile associated with phenotypic changes in lung fibroblasts co-cultured with gold nanoparticle-treated small airway epithelial cells

CT Ng, LYL Yung, HLF Swa, RWY Poh, J Gunaratne… - Biomaterials, 2015 - Elsevier
Despite the availability of toxicity studies on cellular exposure to gold nanoparticles
(AuNPs), there is scarcity of information with regard to the bystander effects induced by …

Toxicological profile of small airway epithelial cells exposed to gold nanoparticles

CT Ng, JJE Li, RL Gurung, MP Hande… - Experimental …, 2013 - journals.sagepub.com
Gold nanoparticles (AuNPs) have diverse applications in the biomedical industry such as in
diagnosis, labeling, delivering and sensing. Despite their prevalent medical use …

Integrative functional transcriptomic analyses implicate specific molecular pathways in pulmonary toxicity from exposure to aluminum oxide nanoparticles

X Li, C Zhang, Q Bian, N Gao, X Zhang, Q Meng… - …, 2016 - Taylor & Francis
Gene expression profiling has developed rapidly in recent years and it can predict and
define mechanisms underlying chemical toxicity. Here, RNA microarray and computational …

Silver, gold, and iron oxide nanoparticles alter miRNA expression but do not affect DNA methylation in HepG2 cells

K Brzóska, I Grądzka, M Kruszewski - Materials, 2019 - mdpi.com
The increasing use of nanoparticles (NPs) in various applications entails the need for
reliable assessment of their potential toxicity for humans. Originally, studies concerning the …

Transplacental clastogenic and epigenetic effects of gold nanoparticles in mice

R Balansky, M Longobardi, G Ganchev… - Mutation Research …, 2013 - Elsevier
The broad application of nanotechnology in medicine, biology, and pharmacology is leading
to a dramatic increase of the risk of direct contact of nanoproducts, among which gold …

Gold nanoparticles induce oxidative damage in lung fibroblasts in vitro

JJ Li, LI Zou, D Hartono, CN Ong, BH Bay… - Advanced …, 2008 - Wiley Online Library
Abstract Evaluation of the health risks associated with the use of nanometer‐sized particles
constitutes an important research field. Here, the effect of gold nanoparticles (AuNPs) on …

RNA-sequencing reveals long-term effects of silver nanoparticles on human lung cells

AR Gliga, S Di Bucchianico, J Lindvall, B Fadeel… - Scientific reports, 2018 - nature.com
Despite a considerable focus on the adverse effects of silver nanoparticles (AgNPs) in
recent years, studies on the potential long-term effects of AgNPs are scarce. The aim of this …

Insights into the epigenetic effects of nanomaterials on cells

J Yu, XJ Loh, Y Luo, S Ge, X Fan, J Ruan - Biomaterials science, 2020 - pubs.rsc.org
With the development of nanotechnology, nanomaterials are increasingly being applied in
health fields, such as biomedicine, pharmaceuticals, and cosmetics. Concerns have …