ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis

B Wang, Y Wang, J Zhang, C Hu, J Jiang, Y Li… - Archives of …, 2023 - Springer
Reactive oxygen species (ROS) mediate lipid peroxidation and produce 4-hydroxynonenal
and other related products, which play an important role in the process of cell death …

Reactive oxygen species‐induced lipid peroxidation in apoptosis, autophagy, and ferroptosis

LJ Su, JH Zhang, H Gomez, R Murugan… - Oxidative medicine …, 2019 - Wiley Online Library
Reactive oxygen species‐(ROS‐) induced lipid peroxidation plays a critical role in cell death
including apoptosis, autophagy, and ferroptosis. This fundamental and conserved …

[HTML][HTML] ROS induced lipid peroxidation and their role in ferroptosis

HT Endale, W Tesfaye, TA Mengstie - Frontiers in cell and …, 2023 - frontiersin.org
Reactive oxygen species (ROS) play a crucial part in the process of cell death, including
apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate …

[HTML][HTML] Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis

L Rochette, G Dogon, E Rigal, M Zeller… - International journal of …, 2022 - mdpi.com
Regulated cell death (RCD) has a significant impact on development, tissue homeostasis,
and the occurrence of various diseases. Among different forms of RCD, ferroptosis is …

[HTML][HTML] Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

B Wiernicki, H Dubois, YY Tyurina, B Hassannia… - Cell death & …, 2020 - nature.com
Lipid peroxidation (LPO) drives ferroptosis execution. However, LPO has been shown to
contribute also to other modes of regulated cell death (RCD). To clarify the role of LPO in …

Reactive oxygen species (ROS) regulates different types of cell death by acting as a rheostat

GE Villalpando-Rodriguez… - Oxidative Medicine and …, 2021 - Wiley Online Library
Reactive oxygen species (ROS) are essential for cellular signaling and response to stress.
The level of ROS and the type of ROS determine the ability of cells to undergo cell death …

Signaling pathways and defense mechanisms of ferroptosis

J Liu, R Kang, D Tang - The FEBS journal, 2022 - Wiley Online Library
As a type of lytic cell death driven by unrestricted lipid peroxidation and subsequent plasma
membrane damage, ferroptosis occurs and develops because of sophisticated signals and …

[HTML][HTML] Mechanisms of ferroptosis and relations with regulated cell death: a review

P Lei, T Bai, Y Sun - Frontiers in physiology, 2019 - frontiersin.org
Ferroptosis is a newly identified form of nonapoptotic regulated cell death (RCD)
characterized by iron-dependent accumulation of lipid peroxides. It is morphologically and …

[HTML][HTML] NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

M Dodson, R Castro-Portuguez, DD Zhang - Redox biology, 2019 - Elsevier
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of
the cellular antioxidant response, controlling the expression of genes that counteract …

[HTML][HTML] Oxidative damage and antioxidant defense in ferroptosis

F Kuang, J Liu, D Tang, R Kang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Many new types of regulated cell death have been recently implicated in human health and
disease. These regulated cell deaths have different morphological, genetic, biochemical …