Recent studies have begun to reveal critical roles for the brain's professional phagocytes,
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …

Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions
such as Alzheimer's disease. However, the specific role of reactive astrocytes is still …

Microglia as tissue macrophages contribute to the defense and maintenance of central
nervous system (CNS) homeostasis. Little is known about the epigenetic signals controlling …

Neuroinflammation, characterized by activated microglia and infiltrating T cells, is a
prominent pathological feature in neurodegenerative diseases. However, whether this …

Severe traumatic brain injury (TBI) elicits destruction of both gray and white matter, which is
exacerbated by secondary proinflammatory responses. Although white matter injury (WMI) is …

Alzheimer's disease (AD) is an irreversible neurodegenerative illness and the exact etiology
of the disease remains unknown. It is characterized by long preclinical and prodromal …

Microglia play a key role in innate immunity in Alzheimer disease (AD), but their role as
antigen-presenting cells is as yet unclear. Here we found that amyloid β peptide (Aβ) …

Yes-associated protein (YAP) is a key transcriptional cofactor of the Hippo pathway, critical
for the development of multiple organs. However, its role in the developing brain remains …

Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that
populate the brain parenchyma during development. During development and homeostasis …

Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …