The cohesin complex has an essential role in maintaining genome organization. However,
its role in gene regulation remains largely unresolved. Here we report that the cohesin …

Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates
cohesin's ATPase and is essential for loop extrusion, but its requirement for cohesin loading …

Cohesin-mediated loop extrusion has been shown to be blocked at specific cis-elements,
including CTCF sites, producing patterns of loops and domain boundaries along …

Mammalian genomes contain several billion base pairs of DNA that are packaged in
chromatin fibres. At selected gene loci, cohesin complexes have been proposed to arrange …

Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin
into chromatin loops, and topologically associated domains,,,, which have important roles in …

Background The cohesin complex mediates sister chromatid cohesion and regulates gene
transcription. Prior studies show that cohesin preferentially binds and regulates genes that …

Transcription factors control cell-specific gene expression programs through interactions
with diverse coactivators and the transcription apparatus. Gene activation may involve DNA …

Cohesin is a ring-shaped complex, conserved from yeast to human, that was named for its
ability to mediate sister chromatid cohesion. This function is essential for chromosome …

Over the past decade it has emerged that the cohesin protein complex, which functions in
sister chromatid cohesion, chromosome segregation, and DNA repair, also regulates gene …

The cohesin complex, discovered through its role in sister chromatid cohesion, also plays
roles in gene expression and development in organisms from yeast to human. This review …