[HTML][HTML] Animal Models, Pathogenesis, and Potential Treatment of Thoracic Aortic Aneurysm
Y Wang, IS Panicker, J Anesi, O Sargisson… - International Journal of …, 2024 - mdpi.com
Thoracic aortic aneurysm (TAA) has a prevalence of 0.16–0.34% and an incidence of 7.6
per 100,000 person-years, accounting for 1–2% of all deaths in Western countries …
per 100,000 person-years, accounting for 1–2% of all deaths in Western countries …
Pathophysiology of thoracic aortic aneurysm (TAA): is it not one uniform aorta? Role of embryologic origin
JM Ruddy, JA Jones, JS Ikonomidis - Progress in cardiovascular diseases, 2013 - Elsevier
Thoracic aortic aneurysm (TAA) is a clinically silent and potentially fatal disease whose
pathophysiology is poorly understood. Application of data derived from animal models and …
pathophysiology is poorly understood. Application of data derived from animal models and …
Medical therapy of thoracic aortic aneurysms: are we there yet?
P Danyi, JA Elefteriades, IS Jovin - Circulation, 2011 - Am Heart Assoc
An aneurysm is defined as a localized dilatation of a vessel of 50% of the normal diameter
and includes all layers of the given vessel. 1 Aortic aneurysms are divided into thoracic …
and includes all layers of the given vessel. 1 Aortic aneurysms are divided into thoracic …
[HTML][HTML] Accentuating and opposing factors leading to development of thoracic aortic aneurysms not due to genetic or inherited conditions
SW Rabkin - Frontiers in Cardiovascular Medicine, 2015 - frontiersin.org
Understanding and unraveling the pathophysiology of thoracic aortic aneurysm (TAA), a
vascular disease with a potentially high-mortality rate, is one of the next frontiers in vascular …
vascular disease with a potentially high-mortality rate, is one of the next frontiers in vascular …
[HTML][HTML] Transforming growth factor-β and the renin-angiotensin system in syndromic thoracic aortic aneurysms: implications for treatment
DCH van Dorst, NP de Wagenaar… - … Drugs and Therapy, 2021 - Springer
Thoracic aortic aneurysms (TAAs) are permanent pathological dilatations of the thoracic
aorta, which can lead to life-threatening complications, such as aortic dissection and rupture …
aorta, which can lead to life-threatening complications, such as aortic dissection and rupture …
[HTML][HTML] Aortic aneurysms: current pathogenesis and therapeutic targets
MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …
Altered transforming growth factor-beta signaling in a murine model of thoracic aortic aneurysm
JA Jones, JR Barbour, RE Stroud, S Bouges… - Journal of vascular …, 2008 - karger.com
Abstract Objective: Thoracic aortic aneurysms (TAAs) develop by a multifactorial process
involving maladaptive signaling pathways that alter the aortic vascular environment …
involving maladaptive signaling pathways that alter the aortic vascular environment …
[HTML][HTML] Cellular, Molecular and Clinical Aspects of Aortic Aneurysm—Vascular Physiology and Pathophysiology
D Domagała, K Data, H Szyller, M Farzaneh… - Cells, 2024 - mdpi.com
A disturbance of the structure of the aortic wall results in the formation of aortic aneurysm,
which is characterized by a significant bulge on the vessel surface that may have …
which is characterized by a significant bulge on the vessel surface that may have …
Therapeutics targeting drivers of thoracic aortic aneurysms and acute aortic dissections: insights from predisposing genes and mouse models
DM Milewicz, SK Prakash… - Annual review of medicine, 2017 - annualreviews.org
Thoracic aortic diseases, including aneurysms and dissections of the thoracic aorta, are a
major cause of morbidity and mortality. Risk factors for thoracic aortic disease include …
major cause of morbidity and mortality. Risk factors for thoracic aortic disease include …
[HTML][HTML] Insights on the pathogenesis of aneurysm through the study of hereditary aortopathies
Thoracic aortic aneurysms (TAA) are permanent and localized dilations of the aorta that
predispose patients to a life-threatening risk of aortic dissection or rupture. The identification …
predispose patients to a life-threatening risk of aortic dissection or rupture. The identification …