Rapid advances in molecular biological techniques have made it possible to study disease
pathogenesis at a genomic level. T cell receptor (TCR) gene rearrangement is an important …

Polymerase chain reaction (PCR)-directed amplification and sequencing of rearranged
immune genes for identification of clone-specific markers are increasingly being used in …

Reliable detection of clonal T cell receptor beta (TCRB) gene rearrangements is essential
for clonality assessment of suspect T cell proliferations. Since no appropriate Southern blot …

A series of T-cell proliferations in peripheral blood, bone marrow, or tissue samples, together
with seven T-cell lines, were analysed for clonality. The technique used employs the …

The diagnosis of T-cell lymphoproliferative disorders, which frequently involve the skin and
other extranodal sites, is often problematic because of the difficulty in establishing clonality …

The distinction between benign polyclonal and malignant monoclonal lymphoid disorders by
morphology or immunophenotyping is frequently difficult. Therefore, the demonstration of …

Molecular analysis of T cell receptor (TCR) genes is frequently used to prove or exclude
clonality and thereby support the diagnosis of suspect T cell proliferations. PCR techniques …

The author reviews the immunophenotypic profiles displayed by the major clinicopathologic
categories of T cell neoplasia, the immunophenotypic criteria useful in the immunodiagnosis …

Clonality testing in T-lymphoproliferations has technically become relatively easy to perform
in routine laboratories using standardized multiplex polymerase chain reaction protocols for …

To gain more insight into initiation and regulation of T cell receptor (TCR) gene
rearrangement during human T cell development, we analyzed TCR gene rearrangements …