The blood–brain barrier (BBB) represents a major obstacle to the delivery of drugs to the
central nervous system. The combined use of low-intensity pulsed ultrasound waves and …

We sought to determine whether transtemporal-applied 1-MHz ultrasound–induced
microbubble destruction may be a safe method of transiently altering blood brain barrier …

Numerous animal studies have demonstrated that ultrasound bursts combined with a
microbubble-based ultrasound contrast agent can temporarily disrupt the blood-brain barrier …

Focused ultrasound (FUS) combined with microbubbles is a non-invasive method for
targeted, reversible disruption of the blood–brain barrier (FUS-BBB opening). This approach …

Focused ultrasound (FUS) in the presence of microbubbles transiently and reversibly opens
the blood-brain barrier (BBB) in rodents and humans, thereby providing a time window for …

Ultrasound and microbubbles (MBs) offer a noninvasive method of temporarily enhancing
blood–brain barrier (BBB) permeability to therapeutics. To reduce off‐target effects, it is …

The blood–brain barrier is a specialized protective structure in the central nervous system,
which is critical for maintaining brain homeostasis and low permeability to control the …

The blood–brain barrier (BBB) is a specialized system of capillary endothelial cells that
protects the brain from harmful substances in the blood stream, while supplying the brain …

This review delves into the innovative technology of Blood-Brain Barrier (BBB) opening with
low-intensity focused ultrasound in combination with microbubbles (LIFU-MB), a promising …

Focused ultrasound (FUS) in combination with microbubbles (MBs) has been successfully
used in the delivery of various-size therapeutic agents across the blood–brain barrier (BBB) …