Rationale: Low-attenuation areas assessed by computed tomography reflect the extent of
pathological emphysema and correlate with airflow limitation and mortality in patients with …

Rationale: Emphysema occurs in distinct pathologic patterns, but little is known about the
epidemiologic associations of these patterns. Standard quantitative measures of …

Rationale: The rate of decline of lung function is greater than age-related change in a
substantial proportion of patients with chronic obstructive pulmonary disease, even after …

Emphysema distribution is associated with chronic obstructive pulmonary disease. It is,
however, unknown whether computed tomography (CT)-quantified emphysema distribution …

Background: Chronic obstructive pulmonary disease (COPD) is characterised by both an
accelerated decline in lung function and periods of acute deterioration in symptoms termed …

Computed tomography (CT) scanning allows precise assessment of both the extent and
distribution of emphysema. There has been little work on the relationship between the …

Patients with fixed airflow limitation are grouped under the heading of chronic obstructive
pulmonary disease (COPD). The authors investigated whether COPD patients have distinct …

Rationale: There is limited knowledge about the relationship between respiratory symptoms
and quantitative high-resolution computed tomography measures of emphysema and airway …

Background The progression of chronic obstructive pulmonary disease (COPD)
considerably varies among patients. Those with emphysema identified by quantitative …

Objectives To investigate the association between emphysema heterogeneity in spatial
distribution, pulmonary function and disease severity. Methods and Materials We …