Objectives: Drugs that inhibit the reuptake of serotonin, norepinephrine, and/or dopamine
are widely used for treating depressive disorders and have emerged as effective drugs for …

Purpose: Anticonvulsants, antidepressants, local anesthetics, sodium channel blockers,
drugs such as narcotic analgesics but also on alternative therapies has been extensively …

Objective: To study the analgesic activity of venlafaxine and its interactions with tramadol,
celecoxib and amlodipine. Materials and Methods: Antinociceptive action of venlafaxine (5 …

ABSTRACT Background and Aim: Neuropathic pain results from nerve injury and
nortriptyline, an antidepressant drug, has been approved for the treatment of several types of …

Introduction: Antidepressant drugs are used in the treatment of pain as an adjuvant or alone.
It has been shown that antidepressant drugs have analgesic effects in various diseases …

Interaction between analgesic and various psychotropic drugs constitute a subject of many
research investigations. Literature data considering this issue are otten inconsistent …

Background: Amitriptyline, duloxetine, and pregabalin are among the most
pharmacotherapeutic, effective treatments for neuropathic pain control. However, the …

Neuropathic pain constitutes a serious therapeutic problem. In most cases polytherapy is
necessary. Tramadol and antidepressants have common mechanisms of action and are …

Background and Purpose: Sedation and somnolence remain serious adverse effects of the
existing analgesics (eg, pregabalin, duloxetine) for neuropathic pain. The available …

Objective: To evaluate the antinociceptive/analgesic action of selective serotonin reuptake
inhibitors (SSRIs; fluoxetine, escitalopram) and atypical antidepressants (mirtazapine …