Objective: To review the available evidence regarding the utility of the currently available β-
lactam/β-lactamase inhibitor combinations (BLICs) as well as the emerging body of data for …

ABSTRACT Introduction: Antimicrobial resistance in Gram-negative pathogens is a
significant threat to global health. β-Lactams (BL) are one of the safest and most-prescribed …

Antibiotic resistance caused by β-lactamase production continues to present a growing
challenge to the efficacy of β-lactams and their role as the most important class of clinically …

The limited armamentarium against drug-resistant Gram-negative bacilli has led to the
development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this …

Abstract Purpose of Review To describe the mechanisms and clinical relevance of emergent
resistance to three recently introduced beta-lactamase inhibitor combinations (BLICs) active …

Combinations of β-lactams and β-lactamase inhibitors have become one of the most
successful antibacterial strategies in our global battle against bacterial infections. The …

The use of β-lactamase inhibitors in combination with β-lactam antibiotics is currently the
most successful strategy to combat a specific resistance mechanism. Their broad spectrum …

Abstract β-Lactamase inhibitors (BLIs) have played an important role in combatting β-lactam
resistance in Gram-negative bacteria, but their effectiveness has diminished with the …

Tazobactam was the most recent β‐lactamase inhibitor to be approved in 1993. Since the
approval of piperacillin–tazobactam, the complexity of β‐lactamase–mediated resistance …

Infect Dis Clin N Am 30 (2016) 441–464 http://dx. doi. org/10.1016/j. idc. 2016.02. 007 id.
theclinics. com 0891-5520/16/$–see front matter© 2016 Elsevier Inc. All rights reserved …