Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …

This review is aimed to provide to an “educated but non-expert” readership and an overview
of the scientific, commercial, and ethical importance of investigating the crystalline forms …

In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

Crystal form can be crucial to the performance of a dosage form. This is especially true for
compounds that have intrinsic barriers to drug delivery, such as low aqueous solubility, slow …

Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient
are the major constraints during the development of new product. Various approaches have …

Many drugs exist in the crystalline solid state due to reasons of stability and ease of handling
during the various stages of drug development. Crystalline solids can exist in the form of …

Cocrystal is a concept of the supramolecular chemistry which is gaining the extensive
interest of researchers from pharmaceutical and chemical sciences and of drug regulatory …

" Polymorphism in the Pharmaceutical Industry-Solid Form and Drug Development"
highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus …

From crystal structure prediction to totally empirical screening, the quest for new crystal
forms has become one of the most challenging issues in the solid state science and …

Pharmaceutical cocrystals belong to a sub-class of cocrystals wherein one of the
components is a drug molecule (or an active pharmaceutical ingredient, API) and the …