The development of antiretroviral therapy (ART) has been effective in suppressing HIV
replication. However, severe drug toxicities due to the therapy and its failure in targeting the …

Introduction: The use of antiretroviral therapy has led to a significant decrease in morbidity
and mortality in HIV-infected individuals. Nevertheless, gene-based therapies represent a …

Highlights•HIV provirus in infected cells can be inactivated with CRISPR–
Cas9.•Combinatorial CRISPR–Cas9 attack can prevent viral escape.•Both mutation and …

Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) remains
a major health hazard despite significant advances in prevention and treatment of HIV …

Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …

The CRISPR/Cas9 system has been developed as a powerful tool for targeted gene editing.
As a result of technical enhancements in recent years, this technology has become the …

CRISPR/Cas9 is an adaptive immune system where bacteria and archaea have evolved to
resist the invading viruses and plasmid DNA by creating site-specific double-strand breaks …

The HIV‐1 virus (human immunodeficiency virus) affects 36.9 million people worldwide, with
approximately 900000 deaths in 2017. The virus carrier can develop severe …

Abstract Background The novel endonuclease Cas12b was engineered for targeted
genome editing in mammalian cells and is a promising tool for certain applications because …

Although highly active antiretroviral therapy (HAART) can robustly control human
immunodeficiency virus (HIV) infection, the existence of latent HIV in a form of proviral DNA …