Transcriptional downregulation of E-cadherin appears to be an important event in the
progression of various epithelial tumors. SIP1 (ZEB-2) is a Smad-interacting, multi-zinc …

SIP1/ZEB2 is a member of the δEF-1 family of two-handed zinc finger nuclear factors. The
expression of these transcription factors is associated with epithelial mesenchymal …

Transcriptional repression mechanisms have emerged as one of the crucial processes for
the downregulation of E-cadherin expression during development and tumour progression …

The E-box-binding zinc finger transcription factors Slug and ZEB1 are important repressors
of E-cadherin, contributing to epithelial–mesenchymal transition (EMT) in primary epithelial …

Loss of E-cadherin expression allows carcinoma cells to liberate from the primary site and
enhances invasion and metastasis. The genetic aberration of E-cadherin is a rare event in …

Epithelial-mesenchymal transition (EMT) is important in embryonic development and
tumorigenesis. Smad-interacting protein 1 (SIP1) can induce EMT by repressing the …

E-cadherin protein plays a key role in the establishment and maintenance of adherent
junctions. Recent evidence implicates the transcription factor Snail in the blockage of E …

Loss of expression of the E-cadherin cell-cell adhesion molecule is important in carcinoma
development and progression. Because previous data suggest that loss of E-cadherin …

δEF1 and SIP1 (or Zfhx1a and Zfhx1b, respectively) are the only known members of the
vertebrate Zfh1 family of homeodomain/zinc finger-containing proteins. Similar to other …

Abstract The transcription factors Snail, Slug, and bHLH E47 have been recently described
as direct repressors of E-cadherin and inducers of epithelial-mesenchymal transition (EMT) …