DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics
White adipose tissue (WAT) is a key regulator of systemic energy metabolism, and impaired
WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT …
WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT …
Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis
Abstract DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of
both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A …
both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A …
Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance
Mitochondrial epigenetics is rising as intriguing notion for its potential involvement in aging
and diseases, while the details remain largely unexplored. Here it is shown that among the …
and diseases, while the details remain largely unexplored. Here it is shown that among the …
Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice
Increasing energy expenditure through activation of brown fat thermogenesis is a promising
therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key …
therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key …
Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
Brown adipocytes share the same developmental origin with skeletal muscle. Here we find
that a brown adipocyte-to-myocyte remodeling also exists in mature brown adipocytes, and …
that a brown adipocyte-to-myocyte remodeling also exists in mature brown adipocytes, and …
Functional implications of DNA methylation in adipose biology
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and
economic issue. The dysregulation of adipose tissue biology is central to the development of …
economic issue. The dysregulation of adipose tissue biology is central to the development of …
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation
DNA methylation is a crucial epigenetic modification in the establishment of cell-type-
specific characteristics. However, how DNA methylation is selectively reprogrammed at …
specific characteristics. However, how DNA methylation is selectively reprogrammed at …
DNMT1 is regulated by ATP-citrate lyase and maintains methylation patterns during adipocyte differentiation
T Londoño Gentile, C Lu, PM Lodato… - … and cellular biology, 2013 - Taylor & Francis
During adipocyte differentiation, significant epigenomic changes occur in association with
the implementation of the adipogenic program. We have previously shown that histone …
the implementation of the adipogenic program. We have previously shown that histone …
Dnmt3a is an epigenetic mediator of adipose insulin resistance
D You, E Nilsson, DE Tenen, A Lyubetskaya, JC Lo… - Elife, 2017 - elifesciences.org
Insulin resistance results from an intricate interaction between genetic make-up and
environment, and thus may be orchestrated by epigenetic mechanisms like DNA …
environment, and thus may be orchestrated by epigenetic mechanisms like DNA …
Neuronal Dnmt1 deficiency attenuates diet-induced obesity in mice
EC Bruggeman, JT Garretson, R Wu, H Shi… - Endocrinology, 2018 - academic.oup.com
Aberrant neuronal DNA methylation patterns have been implicated in the promotion of
obesity development; however, the role of neuronal DNA methyltransferases (Dnmts) …
obesity development; however, the role of neuronal DNA methyltransferases (Dnmts) …