White adipose tissue (WAT) is a key regulator of systemic energy metabolism, and impaired
WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT …

Abstract DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of
both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A …

Mitochondrial epigenetics is rising as intriguing notion for its potential involvement in aging
and diseases, while the details remain largely unexplored. Here it is shown that among the …

Increasing energy expenditure through activation of brown fat thermogenesis is a promising
therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key …

Brown adipocytes share the same developmental origin with skeletal muscle. Here we find
that a brown adipocyte-to-myocyte remodeling also exists in mature brown adipocytes, and …

The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and
economic issue. The dysregulation of adipose tissue biology is central to the development of …

DNA methylation is a crucial epigenetic modification in the establishment of cell-type-
specific characteristics. However, how DNA methylation is selectively reprogrammed at …

During adipocyte differentiation, significant epigenomic changes occur in association with
the implementation of the adipogenic program. We have previously shown that histone …

Insulin resistance results from an intricate interaction between genetic make-up and
environment, and thus may be orchestrated by epigenetic mechanisms like DNA …

Aberrant neuronal DNA methylation patterns have been implicated in the promotion of
obesity development; however, the role of neuronal DNA methyltransferases (Dnmts) …