As a highly aggressive bone malignancy, osteosarcoma poses a significant therapeutic
challenge, especially in the setting of metastasis or recurrence. This study aimed to …

Background Osteosarcoma is a highly aggressive type of bone cancer with a poor
prognosis. In the tumor immune microenvironment, T-cell exhaustion can occur due to …

Background: The tumor microenvironment (TME) chiefly consists of tumor cells and tumor-
infiltrating immune cells admixed with the stromal component. Recent studies have shown …

Host immune dysregulation involves in the initiation and development of osteosarcoma
(OS). However, the exact role of immune cells in OS remains unknown. We aimed to …

Objectives: Osteosarcoma is the most common primary malignant tumor in children and
adolescents, and the 5-year survival of osteosarcoma patients gained no substantial …

Osteosarcoma (OS) is a highly invasive malignant neoplasm with poor prognosis. The tumor
microenvironment (TME) plays an essential role in the occurrence and development of OS …

Objective. Currently, clinical classification of osteosarcoma cannot accurately predict the
survival outcomes and responses to chemo‐or immunotherapies. Our goal was to classify …

Osteoclasts (OCs) and regulatory CD4+ T cells (CD4+ Tregs) are important components in
the tumor microenvironment (TME) of osteosarcoma. In this study, we collected six …

Osteosarcoma (OS) is the most common type of primary malignant bone tumor. The high-
throughput sequencing technology has shown potential abilities to illuminate the pathogenic …

Cancer immunotherapy is a promising therapeutic approach, but the prognostic value of
immune-related genes in osteosarcoma (OS) is unknown. Here, Target-OS RNA-seq data …