Ferroptosis nanomedicine: clinical challenges and opportunities for modulating tumor metabolic and immunological landscape

H Yang, X Yao, Y Liu, X Shen, M Li, Z Luo - Acs Nano, 2023 - ACS Publications
Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid
peroxidation, has captured much attention in the field of nanomedicine since it was coined in …

Emerging mechanisms and targeted therapy of ferroptosis in cancer

H Wang, Y Cheng, C Mao, S Liu, D Xiao, J Huang… - Molecular Therapy, 2021 - cell.com
Ferroptosis is an iron-and lipid reactive oxygen species (ROS)-dependent form of
programmed cell death that is distinct from other forms of regulatory cell death at the …

Ferroptosis: the silver lining of cancer therapy

Z Tang, Z Huang, Y Huang, Y Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Regulatory cell death has been a major focus area of cancer therapy research to improve
conventional clinical cancer treatment (eg chemotherapy and radiotherapy). Ferroptosis, a …

A prospective strategy leveraging nanomedicine for cancer therapy: pouring ferroptosis on apoptosis

Y Xia, J Zhang, G Liu - Nano Today, 2023 - Elsevier
As a fundamental process of the programmed cell death, apoptosis has endowed
nanomedicine broad horizons to treat tumor. However, apoptosis-resistance elicited by …

Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Nanomaterial-induced ferroptosis for cancer specific therapy

M Liu, B Liu, Q Liu, K Du, Z Wang, N He - Coordination Chemistry Reviews, 2019 - Elsevier
Ferroptosis is a new form of nonapoptotic programmed cell death characterized by iron-
dependent accumulation of lipid hydroperoxides to lethal levels. An increasing number of …

Recent progress on targeting ferroptosis for cancer therapy

G Xu, H Wang, X Li, R Huang, L Luo - Biochemical Pharmacology, 2021 - Elsevier
Ferroptosis is a new mode of cell death different from cell necrosis, autophagy, apoptosis,
and pyroptosis, which depends on the accumulation of reactive oxygen species (ROS) …

Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti‐tumor immunity

L Shi, Y Liu, M Li, Z Luo - The FEBS Journal, 2022 - Wiley Online Library
Regulated cell death (RCD) is a vital event in various physiological and pathological
processes. Ferroptosis is a newly described RCD, which is driven by iron accumulation and …

Targeting ferroptosis as a vulnerability in cancer

G Lei, L Zhuang, B Gan - Nature Reviews Cancer, 2022 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions

G Lei, L Zhuang, B Gan - Cancer cell, 2024 - cell.com
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …