The state and behaviour of a cell can be influenced by both genetic and environmental
factors. In particular, tumour progression is determined by underlying genetic aberrations …

Defining the transition from benign to malignant tissue is fundamental to improving early
diagnosis of cancer. Here we use a systematic approach to study spatial genome integrity in …

Genome sequencing of cancers often reveals mosaics of different subclones present in the
same tumour,–. Although these are believed to arise according to the principles of somatic …

Abstract Characterization of the molecular function of the human genome and its variation
across individuals is essential for identifying the cellular mechanisms that underlie human …

Recent technological innovations have enabled the high-throughput quantification of gene
expression and epigenetic regulation within individual cells, transforming our understanding …

Transcript function is determined by sequence elements arranged on an individual RNA
molecule. Variation in transcripts can affect messenger RNA stability, localization and …

Genomic analysis provides insights into the role of copy number variation in disease, but
most methods are not designed to resolve mixed populations of cells. In tumours, where …

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Cellular function in tissue is dependent on the local environment, requiring new methods for
spatial mapping of biomolecules and cells in the tissue context. The emergence of spatial …

Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …