Sickle cell disease (SCD) and β-thalassemia are among the most common inherited
diseases, affecting millions of persons globally. It is estimated that 5–7% of the world's …

Thalassemia and sickle cell disease (SCD) are disorders of hemoglobin that affect millions
of people worldwide. The carrier states for these diseases arose as common, balanced …

Sickle cell disease is an umbrella term for a group of hemoglobinopathies characterized by
the presence of 2 β-globin gene mutations or deletions, at least 1 of which is the point …

Abstract β-Thalassemia major and sickle cell disease (SCD) are among the most common
hereditary disorders worldwide. The supportive treatment of β-thalassemia major requires …

In sickle cell disease, a single base pair substitution in the gene encoding the β-globin chain
of the haemoglobin molecule gives rise to a surprisingly broad spectrum of …

Thalassaemias result from mutations of the globin genes that cause reduced or absent
haemoglobin production and thus interfere with the critical function of oxygen delivery. They …

Sickle cell diseases are defined as genetic conditions in which at least one β globin gene
allele carries the βS (6V) mutation, associated with characteristic vascular occlusion …

Hemoglobinopathies are genetic disorders that lead to abnormal structure of the
hemoglobin molecule. Genetic mutation results in major changes in the hemoglobin …

Although sickle cell anemia was the first molecular disease to be identified, its complex and
fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin …

Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …