The application of inorganic chemistry to medicine is a rapidly developing field, and novel
therapeutic and diagnostic metal complexes are now having an impact on medical practice …

The limitations of cisplatin as an anticancer drug have stimulated the search for other
antitumor-active platinum complexes with improved pharmacological properties. The two …

Many international researchers have strived to understand the mechanism of action or
improve the efficacy of inorganic coordination compounds that have been identified to …

Encouraged by the worldwide success of cisplatin in the field of cancer chemotherapy,
intensive works have been conducted to explore more platinum coordination complexes as …

Platinum (II) complexes are widely employed in cancer chemotherapy, but their efficacy
against the majority of malignancies is limited. The reasons for this failure are a combination …

Research in the field of bioinorganic chemistry has been stimulated by the worldwide
success of the anticancer drug cisplatin. 40 years after the first report about its biological …

Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

cisplatin (cis-Diamminedichloroplatinum (II)) is now clinically used as one of the most
effective anticancer drugs in the treatment of a variety of human solid tumors, such as …

Cisplatin, carboplatin and oxaliplatin continue to be among the most efficient anticancer
drugs in world-wide clinical use so far. In particular, cisplatin has shown a remarkable …

Over the past two decades, platinum-based drugs (cis-platin and, latterly, the less toxic
analogue carboplatin) have conferred significant therapeutic benefit to a large number of …