The adrenal gland is a source of sex steroid precursors, and its activity is particularly
relevant during fetal development and adrenarche. Following puberty, the synthesis of …

For many decades, the prevailing paradigm in endocrinology was that testosterone and 5α-
dihydrotestosterone are the only potent androgens in the context of human physiology. The …

The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been
written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has …

Clinical significance of 11-oxygenated androgens : Current Opinion in Endocrinology,
Diabetes and Obesity Clinical significance of 11-oxygenated androgens : Current Opinion …

Objective 11-oxygenated androgens significantly contribute to the circulating androgen pool.
Understanding the physiological variation of 11-oxygenated androgens and their …

The androgen precursors, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are
produced in high amounts by the adrenal cortex primarily in humans and a few other …

Context The gonads are the major source of sex steroids during reproductive ages. The
gonadal function declines abruptly in women and gradually in men. The adrenals produce …

Abstract 11β-Hydroxyandrostenedione (11OHA4), which is unique to the adrenal, was first
isolated from human adrenal tissue in the fifties. It was later shown in the sixties that 11β …

Context The ovaries and adrenals are sources of androgens in women. Although
dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), and testosterone (T) all decline …

Context The human adrenal is the dominant source of androgens in castration-resistant
prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone …