Recent studies have shown that in addition to being major constituents of the atheromatous
core, solid cholesterol crystals (CCs) promote atherosclerotic lesion development and …

Atherosclerosis is driven by an inflammatory milieu in the walls of artery vessels. Initiated
early in life, it progresses to plaque formation and form cell accumulation. A culprit in this …

Background: Plaque rupture and/or erosion is the leading cause of cardiovascular events;
however, the process is not well understood. Although certain morphologic characteristics …

Reducing the residual risk of cardiovascular (CV) events in patients with atherosclerosis
continues to be a challenge. Thus, understanding how cholesterol spontaneously self …

Evolution of plaque that is prone to rupture is characterized by inflammation and physical
changes. Accumulation of low-density lipoprotein in the sub-intima provides esterified …

Hyperlipidemia, particularly high low-density lipoprotein (LDL) cholesterol serum levels,
represent an important risk factor for future cardiovascular events, showing both causal and …

Understanding the central role of cholesterol crystals (CCs) in the development and
progression of atherosclerosis provides a useful paradigm for the treatment of the disease …

Plaque rupture and/or erosion are considered the leading cause of cardiovascular events.
To elucidate this process, we demonstrated that during cholesterol crystallization the …

Background and aims Cholesterol crystals (CCs) have been found to be critical in the
evolution and progression of atherosclerotic plaque leading up to rupture. This includes …

The response to arterial wall injury is an inflammatory process, which over time becomes
integral to the development of atherosclerosis and subsequent plaque instability. However …