BCR/ABL oncogene directly controls MHC class I chain-related molecule A expression in chronic myelogenous leukemia
MHC class I chain-related molecules (MIC) participate in immune surveillance of cancer
through engagement of the NKG2D-activating receptor on NK and T cells. Decreased …
through engagement of the NKG2D-activating receptor on NK and T cells. Decreased …
The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D–target-cell interactions
G Sconocchia, M Lau, M Provenzano, K Rezvani… - Blood, 2005 - ashpublications.org
To study natural killer (NK) cell–mediated antileukemic activity in chronic myelogenous
leukemia (CML), we investigated the ability of HLA-matched and mismatched CD56+ cells to …
leukemia (CML), we investigated the ability of HLA-matched and mismatched CD56+ cells to …
Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia
HR Salih, H Antropius, F Gieseke, SZ Lutz, L Kanz… - Blood, 2003 - ashpublications.org
Abstract NKG2D ligands (NKG2DLs) mark malignant cells for recognition by natural killer
(NK) cells and cytotoxic T lymphocytes via the activating immunoreceptor NKG2D. This led …
(NK) cells and cytotoxic T lymphocytes via the activating immunoreceptor NKG2D. This led …
Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity
M Jinushi, FS Hodi, G Dranoff - Proceedings of the National …, 2006 - National Acad Sciences
The activation of NKG2D on innate and adaptive cytotoxic lymphocytes contributes to
immune-mediated tumor destruction. Nonetheless, tumor cell shedding of NKG2D ligands …
immune-mediated tumor destruction. Nonetheless, tumor cell shedding of NKG2D ligands …
Tumor-derived soluble MICs impair CD3+ CD56+ NKT-like cell cytotoxicity in cancer patients
H Wang, D Yang, W Xu, Y Wang, Z Ruan, T Zhao… - Immunology letters, 2008 - Elsevier
Upon ligation with its ligands, the activating receptor NKG2D stimulates or costimulates
CD8+ T cells or NK cells. The inducible gene MHC class I chain-related molecules (MICs) …
CD8+ T cells or NK cells. The inducible gene MHC class I chain-related molecules (MICs) …
Intracellular retention of the NKG2D ligand MHC class I chain-related gene A in human melanomas confers immune privilege and prevents NK cell-mediated …
MB Fuertes, MV Girart, LL Molinero… - The Journal of …, 2008 - journals.aai.org
Most tumors grow in immunocompetent hosts despite expressing NKG2D ligands
(NKG2DLs) such as the MHC class I chain-related genes A and B (MICA/B). However, their …
(NKG2DLs) such as the MHC class I chain-related genes A and B (MICA/B). However, their …
NF-κB regulates expression of the MHC class I-related chain A gene in activated T lymphocytes
LL Molinero, MB Fuertes, MV Girart… - The Journal of …, 2004 - journals.aai.org
MHC class I-related chain A gene (MICA) is a stress-regulated, HLA-related molecule which
exhibits a restricted pattern of expression. MICA protein is up-regulated on different tumor …
exhibits a restricted pattern of expression. MICA protein is up-regulated on different tumor …
Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the …
N Kato, J Tanaka, J Sugita, T Toubai, Y Miura, M Ibata… - Leukemia, 2007 - nature.com
Innate immune cells such as natural killer (NK) cells play a crucial role in antitumor immune
responses. NKG2D is a major activating immunoreceptor expressed in not only NK cells but …
responses. NKG2D is a major activating immunoreceptor expressed in not only NK cells but …
[HTML][HTML] Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer
JD Wu, LM Higgins, A Steinle… - The Journal of …, 2004 - Am Soc Clin Investig
The MHC class I chain–related molecules (MICs) have previously been shown to be
induced on most epithelial tumor cells. Engagement of MIC by the activating immune …
induced on most epithelial tumor cells. Engagement of MIC by the activating immune …
Obstructing shedding of the immunostimulatory MHC class I chain–related gene B prevents tumor formation
JD Wu, CL Atteridge, X Wang, T Seya… - Clinical Cancer Research, 2009 - AACR
Purpose: Clinical observations have suggested that shedding of the MHC class I chain–
related molecule (MIC) may be one of the mechanisms by which tumors evade host …
related molecule (MIC) may be one of the mechanisms by which tumors evade host …