The aim of this study was to explore the feasibility of determining parameters of
cardiovascular function in mice noninvasively by high-temporal-resolution imaging with a …

For cardiovascular research on rodents, small-animal PET has limitations because of the
inherent spatial resolution of the system and because of cardiac motion. A factor analysis …

Derivation of the plasma time–activity curve in murine small-animal PET studies is a
challenging task when tracers that are sequestered by the myocardium are used, because …

The rat heart is an excellent model for the investigation of cardiac physiology and
metabolism. It has been used extensively for ex vivo studies of the normal heart as well as …

PET has become an important noninvasive imaging technique in cardiovascular research
for the characterization of mouse models in vivo. This modality offers unique insight into …

Background—We explored the feasibility of measuring regional tracer activity concentrations
and flow defects in myocardium of rats with a high spatial resolution small-animal PET …

18F-FDG PET can identify areas of myocardial viability and necrosis and provide useful
information on the effectiveness of experimental techniques designed to improve contractile …

Recently, integrated small-animal PET/MRI prototypes that provide isochronous and
coregistered datasets of morphology and function through the simultaneous acquisition of …

We describe and validate a hybrid image and blood sampling (HIBS) method to derive the
input function for quantification of microPET mice data. The HIBS algorithm derives the peak …

Positron emission tomography (PET) has been introduced into small animal research only
recently, but it offers attractive possibilities. Fully validated tracer kinetic approaches used in …