Genomes are self-organized and self-maintained as long, complex macromolecules of
chromatin. The inherent heterogeneity, stochasticity, phase separation, and chromatin …

The cell needs to stably maintain its genome and protect it from uncontrolled modifications
that would compromise its function. At the same time, the genome has to be a plastic …

The organization and dynamics of human genome govern all cellular processes—directly
impacting the central dogma of biology—yet are poorly understood, especially at large …

To understand genomic processes such as transcription, translation or splicing, we need to
be able to study their spatial and temporal organization at the molecular level. Single …

The establishment and maintenance of chromatin states involves multiscale dynamic
processes integrating transcription factor and multiprotein effector dynamics, cycles of …

Chromosome organization and dynamics are involved in regulating many fundamental
processes such as gene transcription and DNA repair. Experiments unveiled that chromatin …

In eukaryotes, the genome is packed into chromosomes, each consisting of large polymeric
fibers made of DNA bound with proteins (mainly histones) and RNA molecules. The nature …

Eukaryotic genomes are packaged into an extensively folded state known as chromatin.
Analysis of the structure of eukaryotic chromosomes has been revolutionized by …

Connecting the molecular structure and function of chromatin across length and timescales
remains a grand challenge to understanding and engineering cellular behaviors. Across five …

Next-generation sequencing techniques have led to a new quantitative dimension in the
biological sciences. In particular, integrating sequencing techniques with biophysical tools …