The brain is a metabolically active organ exhibiting high oxygen consumption and robust
production of reactive oxygen species (ROS). The large amounts of ROS are kept in check …

In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

Increasing evidence suggests that reactive oxygen species (ROS), such as superoxide and
hydrogen peroxide, act as necessary signaling molecules in processes underlying …

Cellular homeostasis plays a critical role in how an organism will develop and age.
Disruption of this fragile equilibrium is often associated with health degradation and …

Reactive oxygen species (ROS) have emerged as regulators of key processes supporting
neuronal growth, function, and plasticity across lifespan. At normal physiological levels, ROS …

Aging is associated with a general decline in physiological functions including cognitive
functions. Given that the hippocampus is known to be critical for certain forms of learning …

Recent advancements and growing attention about free radicals (ROS) and redox signaling
enable the scientific fraternity to consider their involvement in the pathophysiology of …

Significance: Oxidative stress increases in the brain with aging and neurodegenerative
diseases. Previous work emphasized irreversible oxidative damage in relation to cognitive …

Reactive oxygen species (ROS) have long been studied as destructive agents in the context
of nervous system ageing, disease and degeneration. Their roles as signalling molecules …

Aberrant or elevated levels of reactive oxygen species (ROS) can mediate deleterious
cellular effects, including neuronal toxicity and degeneration observed in the etiology of a …