Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period

S Aversa, S Pellegrino, I Barberi… - The Journal of …, 2012 - Taylor & Francis
Reactive oxygen species (ROS) play a critical role in the pathogenesis of various diseases
during pregnancy and the perinatal period. Newborns are more prone to oxidative stress …

Potential utility of melatonin in preeclampsia, intrauterine fetal growth retardation, and perinatal asphyxia

L Marseglia, G D'Angelo, S Manti… - Reproductive …, 2016 - journals.sagepub.com
Aim: Reactive oxygen species play an important role in the pathogenesis of several
diseases during gestation and the perinatal period. During pregnancy, increased oxygen …

[HTML][HTML] Use of melatonin in oxidative stress related neonatal diseases

G D'Angelo, R Chimenz, RJ Reiter, E Gitto - Antioxidants, 2020 - mdpi.com
Reactive oxygen species have a crucial role in the pathogenesis of perinatal diseases.
Exposure to inflammation, infections, or high oxygen concentrations is frequent in preterm …

Oxidative stress of the newborn in the pre‐and postnatal period and the clinical utility of melatonin

E Gitto, S Pellegrino, P Gitto, I Barberi… - Journal of pineal …, 2009 - Wiley Online Library
Newborns, and especially those delivered preterm, are probably more prone to oxidative
stress than individuals later in life. Also during pregnancy, increased oxygen demand …

The usefulness of melatonin in the field of obstetrics and gynecology

R Genario, E Morello, AA Bueno, HO Santos - Pharmacological research, 2019 - Elsevier
Disorders of the female reproductive system, including those associated with hormone
regulation, fertility rate and fetal health, are issues of great concern worldwide. More …

[PDF][PDF] Maternal and placental melatonin: actions and implication for successful pregnancies

L Sagrillo-Fagundes, A Soliman, C Vaillancourt - Minerva Ginecol, 2014 - researchgate.net
Melatonin is one of the main sources of mitochondrial protection and its protective effects are
equal or even better if compared with several consecrated antioxidants. Furthermore, the …

Antenatal melatonin as an antioxidant in human pregnancies complicated by fetal growth restriction—a phase I pilot clinical trial: study protocol

NO Alers, G Jenkin, SL Miller, EM Wallace - BMJ open, 2013 - bmjopen.bmj.com
Background Fetal growth restriction complicates about 5% of pregnancies and is commonly
caused by placental dysfunction. It is associated with increased risks of perinatal mortality …

Melatonin and pregnancy in the human

H Tamura, Y Nakamura, MP Terron, LJ Flores… - Reproductive …, 2008 - Elsevier
The purpose of this systematic review is to access the current state of knowledge concerning
the role for melatonin in human pregnancy. Melatonin is a neuroendocrine hormone …

Phase I pilot clinical trial of antenatal maternally administered melatonin to decrease the level of oxidative stress in human pregnancies affected by pre-eclampsia …

SR Hobson, R Lim, EE Gardiner, NO Alers… - BMJ open, 2013 - bmjopen.bmj.com
Introduction Pre-eclampsia is a common pregnancy condition affecting between 3% and 7%
of women. Unfortunately, the exact pathophysiology of the disease is unknown and as such …

Protective role of melatonin in neonatal diseases

E Gitto, L Marseglia, S Manti… - Oxidative Medicine …, 2013 - Wiley Online Library
Oxidative stress contributes to the severity of several newborn conditions to the extent that
Saugstad coined the phrase “oxygen radical diseases of neonatology.” In order to …