Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth
C Voigt, P May, A Gottschlich… - Proceedings of the …, 2017 - National Acad Sciences
IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating
immune cells in several cancer models. We hypothesized that IL-22 regulation would occur …
immune cells in several cancer models. We hypothesized that IL-22 regulation would occur …
Targeting interleukin-22 for cancer therapy
ABSTRACT Interleukin-22 (IL-22) is a member of IL-10 family of cytokines. IL-22 induces
proliferative and anti-apoptotic signaling pathways and production of anti-microbial …
proliferative and anti-apoptotic signaling pathways and production of anti-microbial …
[HTML][HTML] Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes
IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of
tissues against infection. Although CD4+ helper T lymphocytes (TH) were found as a source …
tissues against infection. Although CD4+ helper T lymphocytes (TH) were found as a source …
IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase
GF Weber, FC Gaertner, W Erl, KP Janssen… - The Journal of …, 2006 - journals.aai.org
IL-22 is a recently discovered cytokine of the IL-10 family that binds to a class II cytokine
receptor composed of IL-22R1 and IL-10R2 c and influences a variety of immune reactions …
receptor composed of IL-22R1 and IL-10R2 c and influences a variety of immune reactions …
Pro-tumour activity of interleukin-22 in HPAFII human pancreatic cancer cells
LM Curd, SE Favors, RK Gregg - Clinical & Experimental …, 2012 - academic.oup.com
Summary Interleukin (IL)-22 is a cytokine involved in inflammatory and wound healing
processes that is secreted primarily by T helper type 17 (Th17) cells. IL-22 receptor (IL-22R) …
processes that is secreted primarily by T helper type 17 (Th17) cells. IL-22 receptor (IL-22R) …
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
SC Liang, XY Tan, DP Luxenberg, R Karim… - The Journal of …, 2006 - rupress.org
Th17 cells are a distinct lineage of effector CD4+ T cells characterized by their production of
interleukin (IL)-17. We demonstrate that Th17 cells also expressed IL-22, an IL-10 family …
interleukin (IL)-17. We demonstrate that Th17 cells also expressed IL-22, an IL-10 family …
Recent advances in IL-22 biology
LA Zenewicz, RA Flavell - International immunology, 2011 - academic.oup.com
Several cell types, in particular epithelial cells, express the receptor for the cytokine IL-22
and upon its recognition produce molecules that are active both locally and systemically …
and upon its recognition produce molecules that are active both locally and systemically …
IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway
Although the Th17 subset and its signature cytokine, interleukin (IL)-17A (IL-17), are
implicated in certain autoimmune diseases, their role in cancer remains to be further …
implicated in certain autoimmune diseases, their role in cancer remains to be further …
Interleukin-17 inhibits tumor cell growth by means of a T-cell–dependent mechanism
F Benchetrit, A Ciree, V Vives, G Warnier… - Blood, The Journal …, 2002 - ashpublications.org
Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine produced by activated CD4+
memory T cells. We previously showed that IL-17 increased the growth rate of human …
memory T cells. We previously showed that IL-17 increased the growth rate of human …
The role of the IL-22/IL-22R1 axis in cancer
Abstract Interleukin-22 (IL-22) is an IL-10 family cytokine produced by T cells and innate
lymphoid cells. The IL-22 signaling pathway orchestrates mucosal immune defense and …
lymphoid cells. The IL-22 signaling pathway orchestrates mucosal immune defense and …