Many tumors evolve sophisticated strategies to evade the immune system, and these
represent major obstacles for efficient antitumor immune responses. Here we explored a …

The success of cancer immunotherapy reveals the power of host immunity on killing cancer
cells and the feasibility to unleash restraints of anti-tumor immunity. However, the …

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

The metabolic reprogramming of tumor cells and immune escape are two major hallmarks of
cancer cells. The metabolic changes that occur during tumorigenesis, enabling survival and …

The role of the immune system in tumor elimination has been shown to be increasingly
ambiguous, as many tumors not only escape recognition by the adaptive immune response …

Immune cells survey and patrol throughout the body and sometimes take residence in niche
environments with distinct cellular subtypes and nutrients that may fluctuate from those in …

Immune checkpoint inhibitors (ICIs) targeting immune checkpoint proteins, such as CTLA-4
and PD-1/PD-L1, have demonstrated remarkable and durable clinical responses in various …

Tumor cells reprogram nutrient acquisition and metabolic pathways to meet their energetic,
biosynthetic, and redox demands. Similarly, metabolic processes in immune cells support …

The link between cancer metabolism and immunosuppression, inflammation and immune
escape has generated major interest in investigating the effects of low pH on tumor …

Simple Summary Both cancer cells and immune cells depend on specific metabolic
programs for their survival and function. Depending on which metabolic changes occur …