[HTML][HTML] Emerging regenerative medicine and tissue engineering strategies for Parkinson's disease

JP Harris, JC Burrell, LA Struzyna, HI Chen… - npj Parkinson's …, 2020 - nature.com
Parkinson's disease (PD) is the second most common progressive neurodegenerative
disease, affecting 1–2% of people over 65. The classic motor symptoms of PD result from …

Cell-based therapies for Parkinson's disease

SC Dyson, RA Barker - Expert Review of Neurotherapeutics, 2011 - Taylor & Francis
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, classically characterized by a triad of motor features: bradykinesia, rigidity and …

[HTML][HTML] Neural grafting for Parkinson's disease: challenges and prospects

TB Stoker, NF Blair, RA Barker - Neural regeneration research, 2017 - journals.lww.com
Parkinson's disease (PD) is a neurodegenerative condition which causes a characteristic
movement disorder secondary to loss of dopaminergic neurons in the substanitia nigra. The …

Treating Parkinson's disease in the 21st century: can stem cell transplantation compete?

PC Buttery, RA Barker - Journal of Comparative Neurology, 2014 - Wiley Online Library
The characteristic and selective degeneration of a unique population of cells—the
nigrostriatal dopamine (DA) neurons—that occurs in Parkinson's disease (PD) has made the …

Restorative approaches in Parkinson's Disease: which cell type wins the race?

AK Meyer, M Maisel, A Hermann, K Stirl… - Journal of the neurological …, 2010 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder and is
characterized by a continuous and selective loss of dopaminergic neurons in the midbrain …

[HTML][HTML] Astrocyte-to-neuron reprogramming and crosstalk in the treatment of Parkinson's disease

Y Wang, Y Xia, L Kou, S Yin, X Chi, J Li, Y Sun… - Neurobiology of …, 2023 - Elsevier
Parkinson's disease (PD) is currently the fastest growing disabling neurological disorder
worldwide, with motor and non-motor symptoms being its main clinical manifestations. The …

[HTML][HTML] Current status of stem cell-derived therapies for Parkinson's disease: from cell assessment and imaging modalities to clinical trials

SE Jang, L Qiu, LL Chan, EK Tan, L Zeng - Frontiers in neuroscience, 2020 - frontiersin.org
Curative therapies or treatments reversing the progression of Parkinson's disease (PD) have
attracted considerable interest in the last few decades. PD is characterized by the gradual …

Stem cells for modeling and therapy of Parkinson's disease

Q Zhang, W Chen, S Tan, T Lin - Human gene therapy, 2017 - liebertpub.com
Parkinson's disease (PD) is the second most frequent neurodegenerative disease after
Alzheimer's disease, which is characterized by a low level of dopamine being expressing in …

[HTML][HTML] Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria

WJ Gordián-Vélez, D Chouhan, RA España… - Brain research …, 2021 - Elsevier
Parkinson's disease is a neurodegenerative disease affecting around 10 million people
worldwide. The death of dopaminergic neurons in the substantia nigra and the axonal fibers …

Tissue engineered nigrostriatal pathway for treatment of Parkinson's disease

LA Struzyna, KD Browne, ZD Brodnik… - Journal of tissue …, 2018 - Wiley Online Library
The classic motor deficits of Parkinson's disease are caused by degeneration of
dopaminergic neurons in the substantia nigra pars compacta, resulting in the loss of their …