Camptothecin (CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat
cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation …

Camptothecin (CPT) is a natural compound with remarkable antitumor activities due to its
special mechanism of inhibiting DNA topoisomerase I. Ophiorrhiza pumila was found to …

Abstract Background Ophiorrhiza pumila (Rubiaceae) is capable of producing camptothecin
(CPT), one monoterpene indole alkaloid extensively employed in the treatment of multiple …

Background The anticancer drug camptothecin (CPT), first isolated from Camptotheca
acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila …

Abstract The Rubiaceae species, Ophiorrhiza pumila, accumulates camptothecin, an anti-
cancer alkaloid with a potent DNA topoisomerase I inhibitory activity, as well as …

Camptothecin is a plant-derived alkaloid and important precursor of clinically used anti-
tumor drugs, but little is known about regulatory mechanism of camptothecin production in …

Ophiorrhiza pumila, as a folk herb belonging to the Rubiaceae family, has become a
potential source of camptothecin (CPT), which is a monoterpenoid indole alkaloid with good …

Camptothecin (CPT) belongs to a group of monoterpenoidindole alkaloids (TIAs) and its
derivatives such as irinothecan and topothecan have been widely used worldwide for the …

Ophiorrhiza pumila (O. pumila; Op) is a medicinal herbaceous plant, which can accumulate
camptothecin (CPT). CPT and its derivatives are widely used as chemotherapeutic drugs for …

Camptothecin is a monoterpenoid indole alkaloid that exhibits anti-tumor activity. In
Ophiorrhiza pumila, production of camptothecin and its related alkaloids was high in the …