[HTML][HTML] Stable Isotope Tracing Analysis in Cancer Research: Advancements and Challenges in Identifying Dysregulated Cancer Metabolism and Treatment …

D Hilovsky, J Hartsell, JD Young, X Liu - Metabolites, 2024 - mdpi.com
Metabolic reprogramming is a hallmark of cancer, driving the development of therapies
targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool …

Metabolomics, metabolic flux analysis and cancer pharmacology

L Liang, F Sun, H Wang, Z Hu - Pharmacology & Therapeutics, 2021 - Elsevier
Metabolic reprogramming is a hallmark of cancer and increasing evidence suggests that
reprogrammed cell metabolism supports tumor initiation, progression, metastasis and drug …

[HTML][HTML] Physiological impact of in vivo stable isotope tracing on cancer metabolism

M Grima-Reyes, A Martinez-Turtos, I Abramovich… - Molecular …, 2021 - Elsevier
Background There is growing interest in the analysis of tumor metabolism to identify cancer-
specific metabolic vulnerabilities and therapeutic targets. Finding of such candidate …

Prospects for clinical cancer metabolomics using stable isotope tracers

AN Lane, TWM Fan, RM Higashi, J Tan… - … and molecular pathology, 2009 - Elsevier
Metabolomics provides a readout of the state of metabolism in cells or tissue and their
responses to external perturbations. For this reason, the approach has great potential in …

Metabolic pathway analysis using stable isotopes in patients with cancer

CR Bartman, B Faubert, JD Rabinowitz… - Nature Reviews …, 2023 - nature.com
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …

[HTML][HTML] Stable isotope tracing metabolomics to investigate the metabolic activity of bioactive compounds for cancer prevention and treatment

FK Choudhury, GL Hackman, A Lodi, S Tiziani - Cancers, 2020 - mdpi.com
A major hallmark of cancer is the metabolic reprogramming of cancer cells to fuel tumor
growth and proliferation. Various plant-derived bioactive compounds efficiently target the …

Cancer cell metabolites: updates on current tracing methods

S Maniam, S Maniam - ChemBioChem, 2020 - Wiley Online Library
Cancer is the second leading cause of death‐1 in 6 deaths globally is due to cancer. Cancer
metabolism is a complex and one of the most actively researched area in cancer biology …

Applications of metabolomics to study cancer metabolism

AK Kaushik, RJ DeBerardinis - … et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
Reprogrammed metabolism supports tumor growth and provides a potential source of
therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has …

[HTML][HTML] Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis

D Weindl, T Cordes, N Battello, SC Sapcariu… - Cancer & …, 2016 - Springer
Background Metabolism gained increasing interest for the understanding of diseases and to
pinpoint therapeutic intervention points. However, classical metabolomics techniques only …

Stable isotope-resolved metabolomics and applications for drug development

TWM Fan, PK Lorkiewicz, K Sellers… - Pharmacology & …, 2012 - Elsevier
Advances in analytical methodologies, principally nuclear magnetic resonance
spectroscopy (NMR) and mass spectrometry (MS), during the last decade have made large …