[HTML][HTML] Stable Isotope Tracing Analysis in Cancer Research: Advancements and Challenges in Identifying Dysregulated Cancer Metabolism and Treatment …
Metabolic reprogramming is a hallmark of cancer, driving the development of therapies
targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool …
targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool …
Metabolomics, metabolic flux analysis and cancer pharmacology
L Liang, F Sun, H Wang, Z Hu - Pharmacology & Therapeutics, 2021 - Elsevier
Metabolic reprogramming is a hallmark of cancer and increasing evidence suggests that
reprogrammed cell metabolism supports tumor initiation, progression, metastasis and drug …
reprogrammed cell metabolism supports tumor initiation, progression, metastasis and drug …
[HTML][HTML] Physiological impact of in vivo stable isotope tracing on cancer metabolism
M Grima-Reyes, A Martinez-Turtos, I Abramovich… - Molecular …, 2021 - Elsevier
Background There is growing interest in the analysis of tumor metabolism to identify cancer-
specific metabolic vulnerabilities and therapeutic targets. Finding of such candidate …
specific metabolic vulnerabilities and therapeutic targets. Finding of such candidate …
Prospects for clinical cancer metabolomics using stable isotope tracers
AN Lane, TWM Fan, RM Higashi, J Tan… - … and molecular pathology, 2009 - Elsevier
Metabolomics provides a readout of the state of metabolism in cells or tissue and their
responses to external perturbations. For this reason, the approach has great potential in …
responses to external perturbations. For this reason, the approach has great potential in …
Metabolic pathway analysis using stable isotopes in patients with cancer
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …
[HTML][HTML] Stable isotope tracing metabolomics to investigate the metabolic activity of bioactive compounds for cancer prevention and treatment
A major hallmark of cancer is the metabolic reprogramming of cancer cells to fuel tumor
growth and proliferation. Various plant-derived bioactive compounds efficiently target the …
growth and proliferation. Various plant-derived bioactive compounds efficiently target the …
Cancer cell metabolites: updates on current tracing methods
Cancer is the second leading cause of death‐1 in 6 deaths globally is due to cancer. Cancer
metabolism is a complex and one of the most actively researched area in cancer biology …
metabolism is a complex and one of the most actively researched area in cancer biology …
Applications of metabolomics to study cancer metabolism
AK Kaushik, RJ DeBerardinis - … et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
Reprogrammed metabolism supports tumor growth and provides a potential source of
therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has …
therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has …
[HTML][HTML] Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis
Background Metabolism gained increasing interest for the understanding of diseases and to
pinpoint therapeutic intervention points. However, classical metabolomics techniques only …
pinpoint therapeutic intervention points. However, classical metabolomics techniques only …
Stable isotope-resolved metabolomics and applications for drug development
TWM Fan, PK Lorkiewicz, K Sellers… - Pharmacology & …, 2012 - Elsevier
Advances in analytical methodologies, principally nuclear magnetic resonance
spectroscopy (NMR) and mass spectrometry (MS), during the last decade have made large …
spectroscopy (NMR) and mass spectrometry (MS), during the last decade have made large …
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